TRPV1 receptor as a therapeutical target for the treatment of migraine

Toshihiko Shimizu

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Migraine is a disorder that involves throbbing head pain with increased sensory sensitivity to light, sound, and head movement. Although the pathophysiology of migraine is still obscure, the excitement of the trigeminovascular system followed by the neurogenic inflammation in the dura mater has been implicated in the development of headaches. In addition, the TRPV1 receptor, which is known as one of the nociceptive receptors has recently been shown to express in the dura mater. These findings indicate an association between the TRPV1 receptor and migraine headaches. Furthermore, it suggests of a possibility that the TRPV1 receptor can act as a new therapeutic target for migraine. First, we reviewed the pathophysiology of migraine and the function of the TRPV1 receptor at first. Next, we introduce the possible therapeutic approaches for the application of this receptor for treating migraine; these approaches include regulation of neurotransmitter release via the TRPV1 receptor, regulation of pain conduction pathways via the TRPV1 receptor, and the regulation of the expression of the TRPV1 receptor.

Original languageEnglish
Pages (from-to)949-956
Number of pages8
JournalBrain and Nerve
Volume61
Issue number8
Publication statusPublished - 2009 Aug

Fingerprint

Migraine Disorders
Dura Mater
Therapeutics
Headache
Neurogenic Inflammation
Photophobia
Head Movements
TRPV1 receptor
Neurotransmitter Agents
Pain

Keywords

  • Botulinum toxin
  • CGRP
  • Epidermal growth factor (ERK)
  • Migraine
  • SNARE (soluble NFS attachment protein receptor)
  • TRPV1

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

TRPV1 receptor as a therapeutical target for the treatment of migraine. / Shimizu, Toshihiko.

In: Brain and Nerve, Vol. 61, No. 8, 08.2009, p. 949-956.

Research output: Contribution to journalArticle

Shimizu, Toshihiko. / TRPV1 receptor as a therapeutical target for the treatment of migraine. In: Brain and Nerve. 2009 ; Vol. 61, No. 8. pp. 949-956.
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