Trypanocidal constituents from Michelia alba

Mohd Razip Asaruddin, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki, Fumiyuki Kiuchi

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

The AcOEt extract of the bark of M. alba D.C. (Magnoliaceae) exhibited killing activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded eight trypanocidal constituents; caryophyllene oxide (1), costunolide (2), dihydrocostunolide (3), parthenolide (4), dihydroparthenolide (5), 11, 13-dehydrolanuginolide (6) santamarine (7) and a new monoterpene (8). The structure of monoterpene 8 was determined to be dehydrolinalool oxide on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 61 μM, 7 μM, 27 μM, 0.04 μM, 0.78 μM, 0.16 μM, 25 μM, and 5 μM, respectively.

Original languageEnglish
Pages (from-to)61-63
Number of pages3
JournalNatural Medicines
Volume57
Issue number2
Publication statusPublished - 2003 Apr 1
Externally publishedYes

Keywords

  • Magnoliaceae
  • Michelia alba
  • Monoterpene
  • Sesquiterpene lactone
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Medicine

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