Trypanocidal Flavonoids from Sophora flavescens

Kenji Matsuo, Michiho Ito, Gisho Honda, Tran Kim Qui, Fumiyuki Kiuchi

Research output: Contribution to journal › Article

8 Citations (Scopus)

Abstract

The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).

Original languageEnglish
Pages (from-to)253-255
Number of pages3
JournalNatural Medicines
Volume57
Issue number6
Publication statusPublished - 2003 Dec 1
Externally publishedYes

Keywords

  • Flavonoid
  • Leguminosae
  • Sophora flavescens
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Medicine

Access to Document

Fingerprint Dive into the research topics of 'Trypanocidal Flavonoids from Sophora flavescens'. Together they form a unique fingerprint.

    • Cite this

    Matsuo, K., Ito, M., Honda, G., Qui, T. K., & Kiuchi, F. (2003). Trypanocidal Flavonoids from Sophora flavescens. Natural Medicines, 57(6), 253-255.