Abstract
The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).
| Original language | English |
|---|---|
| Pages (from-to) | 253-255 |
| Number of pages | 3 |
| Journal | Natural Medicines |
| Volume | 57 |
| Issue number | 6 |
| Publication status | Published - 2003 Dec |
| Externally published | Yes |
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Keywords
- Flavonoid
- Leguminosae
- Sophora flavescens
- Trypanosoma cruzi
ASJC Scopus subject areas
- Molecular Medicine
Cite this
Trypanocidal Flavonoids from Sophora flavescens. / Matsuo, Kenji; Ito, Michiho; Honda, Gisho; Qui, Tran Kim; Kiuchi, Fumiyuki.
In: Natural Medicines, Vol. 57, No. 6, 12.2003, p. 253-255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Trypanocidal Flavonoids from Sophora flavescens
AU - Matsuo, Kenji
AU - Ito, Michiho
AU - Honda, Gisho
AU - Qui, Tran Kim
AU - Kiuchi, Fumiyuki
PY - 2003/12
Y1 - 2003/12
N2 - The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).
AB - The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).
KW - Flavonoid
KW - Leguminosae
KW - Sophora flavescens
KW - Trypanosoma cruzi
UR - http://www.scopus.com/inward/record.url?scp=0442293888&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0442293888&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0442293888
VL - 57
SP - 253
EP - 255
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1861-0293
IS - 6
ER -