Trypanocidal Flavonoids from Sophora flavescens

Kenji Matsuo, Michiho Ito, Gisho Honda, Tran Kim Qui, Fumiyuki Kiuchi

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8 Citations (Scopus)

Abstract

The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-) -kurarinone (2), kushenol L (3), 2′-methoxykurarinone, (5), 7,4′-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM (1), 14 μM (2), 7.1 μM (3), 7.2 μM (4), 6.9 μM (5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).

Original languageEnglish
Pages (from-to)253-255
Number of pages3
JournalNatural Medicines
Volume57
Issue number6
Publication statusPublished - 2003 Dec 1

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Keywords

  • Flavonoid
  • Leguminosae
  • Sophora flavescens
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Molecular Medicine

Cite this

Matsuo, K., Ito, M., Honda, G., Qui, T. K., & Kiuchi, F. (2003). Trypanocidal Flavonoids from Sophora flavescens. Natural Medicines, 57(6), 253-255.