Trypanocidal terpenoids from Laurus nobilis L.

Nahoko Uchiyama, Keiji Matsunaga, Fumiyuki Kiuchi, Gisho Honda, Akiko Tsubouchi, Junko Nakajima-Shimada, Takashi Aoki

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Trypanocidal constituents of dried leaves of Laurus nobilis L. (Lauraceae) were examined. Activity-guided fractionation of the methanol extract resulted in the isolation of two guaianolides, dehydrocostus lactone (1) and zaluzanin D (2), and a new p-menthane hydroperoxide, (1R,4S)-1-hydroperoxy-p-menth-2-en-8-ol acetate (3). The minimum lethal concentrations of these compounds against epimastigotes of Trypanosoma cruzi were 6.3, 2.5, and 1.4 μM, respectively.

Original languageEnglish
Pages (from-to)1514-1516
Number of pages3
JournalChemical and Pharmaceutical Bulletin
Volume50
Issue number11
DOIs
Publication statusPublished - 2002 Nov
Externally publishedYes

Fingerprint

Laurus
Lauraceae
Trypanosoma cruzi
Terpenes
Fractionation
Hydrogen Peroxide
Methanol
Acetates
dehydrocostus lactone
zaluzanin-D

Keywords

  • Guaianolide
  • Lauraceae
  • Laurus nobilis
  • p-menthane hydroperoxide
  • Trypanosoma cruzi

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Chemistry(all)
  • Pharmacology

Cite this

Uchiyama, N., Matsunaga, K., Kiuchi, F., Honda, G., Tsubouchi, A., Nakajima-Shimada, J., & Aoki, T. (2002). Trypanocidal terpenoids from Laurus nobilis L. Chemical and Pharmaceutical Bulletin, 50(11), 1514-1516. https://doi.org/10.1248/cpb.50.1514

Trypanocidal terpenoids from Laurus nobilis L. / Uchiyama, Nahoko; Matsunaga, Keiji; Kiuchi, Fumiyuki; Honda, Gisho; Tsubouchi, Akiko; Nakajima-Shimada, Junko; Aoki, Takashi.

In: Chemical and Pharmaceutical Bulletin, Vol. 50, No. 11, 11.2002, p. 1514-1516.

Research output: Contribution to journalArticle

Uchiyama, N, Matsunaga, K, Kiuchi, F, Honda, G, Tsubouchi, A, Nakajima-Shimada, J & Aoki, T 2002, 'Trypanocidal terpenoids from Laurus nobilis L.', Chemical and Pharmaceutical Bulletin, vol. 50, no. 11, pp. 1514-1516. https://doi.org/10.1248/cpb.50.1514
Uchiyama N, Matsunaga K, Kiuchi F, Honda G, Tsubouchi A, Nakajima-Shimada J et al. Trypanocidal terpenoids from Laurus nobilis L. Chemical and Pharmaceutical Bulletin. 2002 Nov;50(11):1514-1516. https://doi.org/10.1248/cpb.50.1514
Uchiyama, Nahoko ; Matsunaga, Keiji ; Kiuchi, Fumiyuki ; Honda, Gisho ; Tsubouchi, Akiko ; Nakajima-Shimada, Junko ; Aoki, Takashi. / Trypanocidal terpenoids from Laurus nobilis L. In: Chemical and Pharmaceutical Bulletin. 2002 ; Vol. 50, No. 11. pp. 1514-1516.
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