Tryptophan inhibits the [3H]Glutamate uptake into Xenopus oocytes injected with rat brain mRNA

M. Tohda, Hisashi Urushihara, Y. Nomura

Research output: Contribution to journalArticle

Abstract

We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalJapanese Journal of Pharmacology
Volume59
Issue number4
Publication statusPublished - 1992
Externally publishedYes

Fingerprint

Xenopus
Tryptophan
Oocytes
Glutamic Acid
Messenger RNA
Brain
Amino Acid Transport System X-AG
Injections

Keywords

  • Brain mRNA
  • Glutamate uptake
  • Xenopus oocytes

ASJC Scopus subject areas

  • Pharmacology

Cite this

Tryptophan inhibits the [3H]Glutamate uptake into Xenopus oocytes injected with rat brain mRNA. / Tohda, M.; Urushihara, Hisashi; Nomura, Y.

In: Japanese Journal of Pharmacology, Vol. 59, No. 4, 1992, p. 477-479.

Research output: Contribution to journalArticle

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