We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.
|Number of pages||3|
|Journal||The Japanese Journal of Pharmacology|
|Publication status||Published - 1992 Jan|
- Brain mRNA
- Glutamate uptake
- Xenopus oocytes
ASJC Scopus subject areas