Tryptophan Inhibits the [3H]Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

Michihisa Tohda; Hisashi Urushihara; Yasuyuki Nomura

doi:10.1254/jjp.59.477

Tryptophan Inhibits the [³H]Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

Michihisa Tohda, Hisashi Urushihara, Yasuyuki Nomura

Research output: Contribution to journal › Article › peer-review

Abstract

We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

Original language	English
Pages (from-to)	477-479
Number of pages	3
Journal	The Japanese Journal of Pharmacology
Volume	59
Issue number	4
DOIs	https://doi.org/10.1254/jjp.59.477
Publication status	Published - 1992 Jan
Externally published	Yes

Keywords

Brain mRNA
Glutamate uptake
Xenopus oocytes

ASJC Scopus subject areas

Pharmacology

Access to Document

10.1254/jjp.59.477

Cite this

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abstract = "We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.",

keywords = "Brain mRNA, Glutamate uptake, Xenopus oocytes",

author = "Michihisa Tohda and Hisashi Urushihara and Yasuyuki Nomura",

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AU - Tohda, Michihisa

AU - Urushihara, Hisashi

AU - Nomura, Yasuyuki

PY - 1992/1

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KW - Brain mRNA

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KW - Xenopus oocytes

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