Tryptophan Inhibits the [3H]Glutamate Uptake into Xenopus Oocytes Injected with Rat Brain mRNA

Michihisa Tohda, Hisashi Urushihara, Yasuyuki Nomura

Research output: Contribution to journalArticle

Abstract

We characterized the glutamate (Glu) uptake in Xenopus oocytes injected with rat brain mRNA. The Glu uptake into oocytes was higher in mRNA-injected oocytes than in vehicle-injected ones. Na+ omission or addition of tryptophan inhibited the uptake in mRNA-injected oocytes, although it did not affect that in vehicle-injected oocytes. These results suggest that Glu transporters with a tryptophan sensitivity different from that of Glu transporters in native oocytes are expressed after injection of rat brain mRNA.

Original languageEnglish
Pages (from-to)477-479
Number of pages3
JournalThe Japanese Journal of Pharmacology
Volume59
Issue number4
DOIs
Publication statusPublished - 1992 Jan

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Keywords

  • Brain mRNA
  • Glutamate uptake
  • Xenopus oocytes

ASJC Scopus subject areas

  • Pharmacology

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