Abstract
Cell Biology; Metabolomics; Stem Cell Research
| Original language | English |
|---|---|
| Article number | 102090 |
| Journal | iScience |
| Volume | 24 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2021 Feb 19 |
Keywords
- Cell Biology
- Metabolomics
- Stem Cell Research
ASJC Scopus subject areas
- General
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Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells. / Someya, Shota; Tohyama, Shugo; Kameda, Kotaro; Tanosaki, Sho; Morita, Yuika; Sasaki, Kazunori; Kang, Moon Il; Kishino, Yoshikazu; Okada, Marina; Tani, Hidenori; Soma, Yusuke; Nakajima, Kazuaki; Umei, Tomohiko; Sekine, Otoya; Moriwaki, Taijun; Kanazawa, Hideaki; Kobayashi, Eiji; Fujita, Jun; Fukuda, Keiichi.
In: iScience, Vol. 24, No. 2, 102090, 19.02.2021.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells
AU - Someya, Shota
AU - Tohyama, Shugo
AU - Kameda, Kotaro
AU - Tanosaki, Sho
AU - Morita, Yuika
AU - Sasaki, Kazunori
AU - Kang, Moon Il
AU - Kishino, Yoshikazu
AU - Okada, Marina
AU - Tani, Hidenori
AU - Soma, Yusuke
AU - Nakajima, Kazuaki
AU - Umei, Tomohiko
AU - Sekine, Otoya
AU - Moriwaki, Taijun
AU - Kanazawa, Hideaki
AU - Kobayashi, Eiji
AU - Fujita, Jun
AU - Fukuda, Keiichi
N1 - Funding Information: The authors thank Drs. Satoru Okamoto and Kotoe Koseki for analysis of amino acids consumption profiles in culture media (Ajinomoto); Tomoko Haruna, Rei Ohno, Sayaka Kanaami, Chihana Fujita, Miho Yamaguchi, Yui Narita, and Naoko Matsumoto for technical assistance with cell preparation and culture (Department of Cardiology, Keio University); Dr. Erina Sugita for technical assistance with Extracellular Flux Analyzer (Department of Endocrinology, Metabolism and Nephrology, Keio University); and Dr. Kenichiro Kinouchi for fruitful discussions (Department of Endocrinology, Metabolism and Nephrology, Keio University). The authors also thank the Center for iPSC Research and Application, and Kyoto University, for the 253G4 and 201B7 cell lines, and WiCell research institute for H9 ES cells. The present work was mainly supported by Projects for Technological Development, Research Center Network for Realization of Regenerative Medicine by Japan, the Japan Agency for Medical Research and Development (AMED) grant 20bm0404023h0003 to S. Tohyama, and partly supported by the Highway Program for Realization of Regenerative Medicine from AMED grant 19bk0104062h0003 to K.F. HMT Research Grant for Young Leaders in Metabolomics to S. Tohyama, and the Japan Society for the Promotion of Science (JSPS) KAKENHI 19K22626 to S. Tohyama. S. Tohyama and J.F. conceptualized the study; S. Tohyama designed the study; S.S. performed and analyzed most experiments; K.K. S.Tanosaki, Y.M. K.S. M.-I.K. Y.K. M.O. H.T. Y.S. K.N. T.U. O.S. T.M. and H.K. contributed to specific experiments; S. Tohyama and S.S. wrote the original draft; S. Tohyama, J.F. and K.F. wrote, reviewed, and edited the manuscript; S. Tohyama and K.F acquired funding; S. Tohyama, J.F. and K.F. supervised the study. S.S. S. Tohyama, J.F. and K.F. have a patent pending related to this work. K.F. is a co-founder and CEO of Heartseed, Inc. S. Tohyama is an advisor of Heartseed, Inc. S. Tohyama, J.F. H.K. and K.F. own equity in Heartseed, Inc. The remaining authors have no conflicts of interest to disclose. Funding Information: The authors thank Drs. Satoru Okamoto and Kotoe Koseki for analysis of amino acids consumption profiles in culture media (Ajinomoto); Tomoko Haruna, Rei Ohno, Sayaka Kanaami, Chihana Fujita, Miho Yamaguchi, Yui Narita, and Naoko Matsumoto for technical assistance with cell preparation and culture (Department of Cardiology, Keio University); Dr. Erina Sugita for technical assistance with Extracellular Flux Analyzer (Department of Endocrinology, Metabolism and Nephrology, Keio University); and Dr. Kenichiro Kinouchi for fruitful discussions (Department of Endocrinology, Metabolism and Nephrology, Keio University). The authors also thank the Center for iPSC Research and Application, and Kyoto University, for the 253G4 and 201B7 cell lines, and WiCell research institute for H9 ES cells. The present work was mainly supported by Projects for Technological Development, Research Center Network for Realization of Regenerative Medicine by Japan, the Japan Agency for Medical Research and Development (AMED) grant 20bm0404023h0003 to S. Tohyama, and partly supported by the Highway Program for Realization of Regenerative Medicine from AMED grant 19bk0104062h0003 to K.F., HMT Research Grant for Young Leaders in Metabolomics to S. Tohyama, and the Japan Society for the Promotion of Science ( JSPS) KAKENHI 19K22626 to S. Tohyama. Publisher Copyright: © 2021 The Author(s)
PY - 2021/2/19
Y1 - 2021/2/19
N2 - Cell Biology; Metabolomics; Stem Cell Research
AB - Cell Biology; Metabolomics; Stem Cell Research
KW - Cell Biology
KW - Metabolomics
KW - Stem Cell Research
UR - http://www.scopus.com/inward/record.url?scp=85100515708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85100515708&partnerID=8YFLogxK
U2 - 10.1016/j.isci.2021.102090
DO - 10.1016/j.isci.2021.102090
M3 - Article
AN - SCOPUS:85100515708
VL - 24
JO - iScience
JF - iScience
SN - 2589-0042
IS - 2
M1 - 102090
ER -