TFH-IgA responses keep microbiota in check

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

In this issue of Cell Host & Microbe, Kubinak et al. (2015) demonstrate that gut microbiota-mediated signaling through MyD88 in CD4+ T cells induces their differentiation into T follicular helper (TFH) cells that promote affinity-matured microbiota antigen-specific immunoglobulin A (IgA) responses. These TFH-driven IgA responses are essential for maintaining gut bacterial diversity and a healthy microbiota.

Original languageEnglish
Pages (from-to)144-146
Number of pages3
JournalCell Host and Microbe
Volume17
Issue number2
DOIs
Publication statusPublished - 2015 Feb 11

Fingerprint

Microbiota
Immunoglobulin A
Helper-Inducer T-Lymphocytes
T-Lymphocytes
Antigens
Gastrointestinal Microbiome

ASJC Scopus subject areas

  • Immunology and Microbiology(all)
  • Cancer Research
  • Molecular Biology

Cite this

TFH-IgA responses keep microbiota in check. / Honda, Kenya.

In: Cell Host and Microbe, Vol. 17, No. 2, 11.02.2015, p. 144-146.

Research output: Contribution to journalArticle

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