Tubular hydroxyapatite formation through a hydrothermal process from α-tricalcium phosphate with anatase

Masanobu Kamitakahara, Hiroko Takahashi, Koji Ioku

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Hydroxyapatite (HA) is a useful substance because of its biocompatibility and adsorption capability. Tubular HA particles are highly attractive as novel tissue scaffolds and as drug carriers because of their hollow structures. We previously found that tubular HA particles were formed when a mixture of α-tricalcium phosphate (α-TCP) and anatase was hydrothermally treated. However, the formation mechanism is still unclear. In this study, we investigated the effect of anatase on the formation of tubular HA particles. The formation of tubular HA particles was enhanced when a pellet of a mixture of α-TCP and anatase was UV-irradiated before hydrothermal treatment. The tubular HA formation was observed only when anatase particles with adequate size were added in adequate quantities. We found that the surface properties, size, and quantity of the anatase particles were important for the formation of tubular HA particles. The tubular HA particles were not formed in the early stages of the reaction, they were formed only after some crystal growth had occurred. The anatase particles controlled the nucleation and crystal growth of HA.

Original languageEnglish
Pages (from-to)4194-4199
Number of pages6
JournalJournal of Materials Science
Volume47
Issue number9
DOIs
Publication statusPublished - 2012 May
Externally publishedYes

Fingerprint

Durapatite
Hydroxyapatite
Titanium dioxide
Phosphates
Crystallization
Crystal growth
Tissue Scaffolds
titanium dioxide
tricalcium phosphate
Drug Carriers
Biocompatibility
Surface properties
Nucleation
Adsorption

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

Cite this

Tubular hydroxyapatite formation through a hydrothermal process from α-tricalcium phosphate with anatase. / Kamitakahara, Masanobu; Takahashi, Hiroko; Ioku, Koji.

In: Journal of Materials Science, Vol. 47, No. 9, 05.2012, p. 4194-4199.

Research output: Contribution to journalArticle

@article{65563dea2a234916b25dca0827eb6f0a,
title = "Tubular hydroxyapatite formation through a hydrothermal process from α-tricalcium phosphate with anatase",
abstract = "Hydroxyapatite (HA) is a useful substance because of its biocompatibility and adsorption capability. Tubular HA particles are highly attractive as novel tissue scaffolds and as drug carriers because of their hollow structures. We previously found that tubular HA particles were formed when a mixture of α-tricalcium phosphate (α-TCP) and anatase was hydrothermally treated. However, the formation mechanism is still unclear. In this study, we investigated the effect of anatase on the formation of tubular HA particles. The formation of tubular HA particles was enhanced when a pellet of a mixture of α-TCP and anatase was UV-irradiated before hydrothermal treatment. The tubular HA formation was observed only when anatase particles with adequate size were added in adequate quantities. We found that the surface properties, size, and quantity of the anatase particles were important for the formation of tubular HA particles. The tubular HA particles were not formed in the early stages of the reaction, they were formed only after some crystal growth had occurred. The anatase particles controlled the nucleation and crystal growth of HA.",
author = "Masanobu Kamitakahara and Hiroko Takahashi and Koji Ioku",
year = "2012",
month = "5",
doi = "10.1007/s10853-012-6274-9",
language = "English",
volume = "47",
pages = "4194--4199",
journal = "Journal of Materials Science",
issn = "0022-2461",
publisher = "Springer Netherlands",
number = "9",

}

TY - JOUR

T1 - Tubular hydroxyapatite formation through a hydrothermal process from α-tricalcium phosphate with anatase

AU - Kamitakahara, Masanobu

AU - Takahashi, Hiroko

AU - Ioku, Koji

PY - 2012/5

Y1 - 2012/5

N2 - Hydroxyapatite (HA) is a useful substance because of its biocompatibility and adsorption capability. Tubular HA particles are highly attractive as novel tissue scaffolds and as drug carriers because of their hollow structures. We previously found that tubular HA particles were formed when a mixture of α-tricalcium phosphate (α-TCP) and anatase was hydrothermally treated. However, the formation mechanism is still unclear. In this study, we investigated the effect of anatase on the formation of tubular HA particles. The formation of tubular HA particles was enhanced when a pellet of a mixture of α-TCP and anatase was UV-irradiated before hydrothermal treatment. The tubular HA formation was observed only when anatase particles with adequate size were added in adequate quantities. We found that the surface properties, size, and quantity of the anatase particles were important for the formation of tubular HA particles. The tubular HA particles were not formed in the early stages of the reaction, they were formed only after some crystal growth had occurred. The anatase particles controlled the nucleation and crystal growth of HA.

AB - Hydroxyapatite (HA) is a useful substance because of its biocompatibility and adsorption capability. Tubular HA particles are highly attractive as novel tissue scaffolds and as drug carriers because of their hollow structures. We previously found that tubular HA particles were formed when a mixture of α-tricalcium phosphate (α-TCP) and anatase was hydrothermally treated. However, the formation mechanism is still unclear. In this study, we investigated the effect of anatase on the formation of tubular HA particles. The formation of tubular HA particles was enhanced when a pellet of a mixture of α-TCP and anatase was UV-irradiated before hydrothermal treatment. The tubular HA formation was observed only when anatase particles with adequate size were added in adequate quantities. We found that the surface properties, size, and quantity of the anatase particles were important for the formation of tubular HA particles. The tubular HA particles were not formed in the early stages of the reaction, they were formed only after some crystal growth had occurred. The anatase particles controlled the nucleation and crystal growth of HA.

UR - http://www.scopus.com/inward/record.url?scp=84857518013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84857518013&partnerID=8YFLogxK

U2 - 10.1007/s10853-012-6274-9

DO - 10.1007/s10853-012-6274-9

M3 - Article

VL - 47

SP - 4194

EP - 4199

JO - Journal of Materials Science

JF - Journal of Materials Science

SN - 0022-2461

IS - 9

ER -