Tubulointerstitial nephritis and uveitis syndrome: A case with an autoimmune reactivity against retinal and renal antigens

Kaori Shimazaki, Guy V. Jirawuthiworavong, Eddy V. Nguyen, Midori Awazu, Ralph D. Levinson, Lynn K. Gordon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Tubulointerstitial nephritis and uveitis (TINU) generally occurs at young age and has a female preponderance. Renal biopsy reveals interstitial infiltration of inflammatory cells and edema, and the associated intraocular inflammation typically consists of an anterior, bilateral uveitis. The pathogenesis of TINU likely involves both humoral and cellular immunity and is mediated by medications, infectious agents, or other unknown causes. A previous report detected a renal antigen recognized by the serum of a TINU patient. In this report the authors extend these observations to document seroreactivity against a retinal antigen of similar size.

Original languageEnglish
Pages (from-to)51-53
Number of pages3
JournalOcular Immunology and Inflammation
Volume16
Issue number1-2
DOIs
Publication statusPublished - 2008 Jan 1

Keywords

  • Antiretinal reactivity
  • Autoantibody
  • Autoantigen
  • Autoimmune reactivity
  • Tubulointerstitial nephritis and uveitis (TINU)

ASJC Scopus subject areas

  • Immunology and Allergy
  • Ophthalmology

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