TY - JOUR
T1 - Tubulointerstitial nephritis and uveitis syndrome
T2 - A case with an autoimmune reactivity against retinal and renal antigens
AU - Shimazaki, Kaori
AU - Jirawuthiworavong, Guy V.
AU - Nguyen, Eddy V.
AU - Awazu, Midori
AU - Levinson, Ralph D.
AU - Gordon, Lynn K.
PY - 2008/1
Y1 - 2008/1
N2 - Tubulointerstitial nephritis and uveitis (TINU) generally occurs at young age and has a female preponderance. Renal biopsy reveals interstitial infiltration of inflammatory cells and edema, and the associated intraocular inflammation typically consists of an anterior, bilateral uveitis. The pathogenesis of TINU likely involves both humoral and cellular immunity and is mediated by medications, infectious agents, or other unknown causes. A previous report detected a renal antigen recognized by the serum of a TINU patient. In this report the authors extend these observations to document seroreactivity against a retinal antigen of similar size.
AB - Tubulointerstitial nephritis and uveitis (TINU) generally occurs at young age and has a female preponderance. Renal biopsy reveals interstitial infiltration of inflammatory cells and edema, and the associated intraocular inflammation typically consists of an anterior, bilateral uveitis. The pathogenesis of TINU likely involves both humoral and cellular immunity and is mediated by medications, infectious agents, or other unknown causes. A previous report detected a renal antigen recognized by the serum of a TINU patient. In this report the authors extend these observations to document seroreactivity against a retinal antigen of similar size.
KW - Antiretinal reactivity
KW - Autoantibody
KW - Autoantigen
KW - Autoimmune reactivity
KW - Tubulointerstitial nephritis and uveitis (TINU)
UR - http://www.scopus.com/inward/record.url?scp=41649115180&partnerID=8YFLogxK
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U2 - 10.1080/09273940801899772
DO - 10.1080/09273940801899772
M3 - Article
C2 - 18379944
AN - SCOPUS:41649115180
SN - 0927-3948
VL - 16
SP - 51
EP - 53
JO - Ocular Immunology and Inflammation
JF - Ocular Immunology and Inflammation
IS - 1-2
ER -