Tubulointerstitial nephritis and uveitis syndrome with autoantibody directed to renal tubular cells

Hitoshi Wakaki, Hisato Sakamoto, Midori Awazu

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

The pathogenesis of tubulointerstitial nephritis and uveitis (TINU) syndrome remains unknown, but T cell-mediated immune response has been postulated to play a role. On the other hand, TINU syndrome is characterized by hypergammaglobulinemia and high serum immunoglobulin G (IgG) levels, suggesting an involvement of humoral immunity. We describe a case of TINU syndrome in a 13-year-old girl with multiple tubular dysfunctions including renal glucosuria, tubular proteinuria, phosphaturia, uricosuria, and concentrating and acidifying defect. IgG antibody from her serum was reactive against 125-kDa human kidney protein. Immunofluorescence study using mouse kidney revealed that the antibody was against cortical renal tubular cells. The antibody disappeared as the renal symptoms resolved. We suggest that IgG antibody may contribute to tubular dysfunction in some patients with TINU syndrome.

Original languageEnglish
Pages (from-to)1443-1446
Number of pages4
JournalPediatrics
Volume107
Issue number6
DOIs
Publication statusPublished - 2001 Jun 21

Keywords

  • Antibody
  • Hypergammaglobulinemia
  • Kidney
  • Renal tubule
  • Tubulointerstitial nephritis
  • Uveitis

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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