TY - JOUR
T1 - Tumor angiogenesis and dynamic CT in lung adenocarcinoma
T2 - Radiologic-Pathologic correlation
AU - Tateishi, Ukihide
AU - Nishihara, Hiroshi
AU - Watanabe, Satoshi
AU - Morikawa, Toshiaki
AU - Abe, Kazuhiro
AU - Miyasaka, Kazuo
PY - 2001
Y1 - 2001
N2 - Purpose: The purpose of this work was to evaluate the correlation of tumor angiogenesis and dynamic CT in lung adenocarcinoma. Method: Thirty-five consecutive patients with lung adenocarcinoma underwent dynamic chest CT. Maximum attenuation of dynamic CT was compared with microvessel densities (MVDs) and vascular endothelial growth factor (VEGF) expression by immunohistochemistry. Results: The mean peak attenuation (APA) of lung adenocarcinoma correlated with MVD (r = 0.689, p < 0.0001). VEGF positiveness of lung adenocarcinoma was 63%. There was a significant difference in APA between VEGF-positive and -negative lung adenocarcinomas (39.9 ± 3.9 and 24.3 ± 2.3; p < 0.05). The mean MVDs of VEGF-positive adenocarcinomas were significantly higher than those of negative ones (82.5 ± 5.9 and 49.2 ± 7.1; p < 0.05). The mean APA of VEGF-positive lung adenocarcinomas correlated positively with MVD (r = 0.707, p < 0.0001). Conclusion: The APA value of dynamic CT reflects MVD in lung adenocarcinoma. The APA value of dynamic CT might be an index for VEGF-related tumor angiogenesis.
AB - Purpose: The purpose of this work was to evaluate the correlation of tumor angiogenesis and dynamic CT in lung adenocarcinoma. Method: Thirty-five consecutive patients with lung adenocarcinoma underwent dynamic chest CT. Maximum attenuation of dynamic CT was compared with microvessel densities (MVDs) and vascular endothelial growth factor (VEGF) expression by immunohistochemistry. Results: The mean peak attenuation (APA) of lung adenocarcinoma correlated with MVD (r = 0.689, p < 0.0001). VEGF positiveness of lung adenocarcinoma was 63%. There was a significant difference in APA between VEGF-positive and -negative lung adenocarcinomas (39.9 ± 3.9 and 24.3 ± 2.3; p < 0.05). The mean MVDs of VEGF-positive adenocarcinomas were significantly higher than those of negative ones (82.5 ± 5.9 and 49.2 ± 7.1; p < 0.05). The mean APA of VEGF-positive lung adenocarcinomas correlated positively with MVD (r = 0.707, p < 0.0001). Conclusion: The APA value of dynamic CT reflects MVD in lung adenocarcinoma. The APA value of dynamic CT might be an index for VEGF-related tumor angiogenesis.
KW - Computed tomography
KW - Lungs, adenocarcinoma
KW - Lungs, cancer
KW - Vascular endothelial growth factor
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U2 - 10.1097/00004728-200101000-00004
DO - 10.1097/00004728-200101000-00004
M3 - Article
C2 - 11176288
AN - SCOPUS:0035145161
SN - 0363-8715
VL - 25
SP - 23
EP - 27
JO - Journal of Computer Assisted Tomography
JF - Journal of Computer Assisted Tomography
IS - 1
ER -
