Tumour architecture is an independent predictor of outcomes after nephroureterectomy

A multi-institutional analysis of 1363 patients

Mesut Remzi, Andrea Haitel, Vitaly Margulis, Pierre Karakiewizc, Francesco Montorsi, Eiji Kikuchi, Richard Zigeuner, Alon Weizer, Christian Bolenz, Karim Bensalah, Nazareno Suardi, Jay D. Raman, Yair Lotan, Matthias Waldert, Casey K. Ng, Mario Fernández, Theresa M. Koppie, Philipp Ströbel, Wareef Kabbani, Masaru Murai & 6 others Cord Langner, Marco Roscigno, Jeffrey Wheat, Charles C. Guo, Christopher G. Wood, Shahrokh F. Shariat

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

OBJECTIVE: To assess whether tumour architecture can help to refine the prognosis of patients treated with nephroureterectomy (NU) for urothelial carcinoma (UC) of the upper urinary tract (UT), as the prognostic value of tumour architecture (papillary vs sessile) in UTUC remains elusive. PATIENTS AND METHODS: The study included 1363 patients with UTUC and treated with radical NU at 12 centres worldwide. All slides were re-reviewed according to strict criteria by genitourinary pathologists who were unaware of the findings of the original pathology slides and clinical outcomes. Gross tumour architecture was categorized as sessile vs papillary. RESULTS: Papillary growth was identified in 983 patients (72.2%) and sessile growth in 380 (27.8%). The sessile growth pattern was associated with higher tumour grade, more advanced stage, lymphovascular invasion, and metastasis to lymph nodes (all P < 0.001). In multivariable Cox regression analyses that adjusted for the effects of pathological stage, grade and lymph node status, tumour architecture (sessile or papillary) was an independent predictor of cancer recurrence (hazard ratio 1.5, P = 0.002) and cancer-specific mortality (1.6, P = 0.001). Adding tumour architecture increased the predictive accuracy of a model that comprised pathological stage, grade and lymph node status for predicting cancer recurrence and cancer-specific death by a minimal but statistically significant margin (gain in predictive accuracy 1% and 0.5%, both P < 0.001). CONCLUSION: The tumour architecture of UTUC is associated with established features of biologically aggressive disease, and more importantly, with prognosis after radical NU. Including tumour architecture in predictive models for disease progression should be considered, aiming to identify patients who might benefit from early systemic therapeutic intervention.

Original languageEnglish
Pages (from-to)307-311
Number of pages5
JournalBJU International
Volume103
Issue number3
DOIs
Publication statusPublished - 2009 Feb

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Neoplasms
Lymph Nodes
Growth
Recurrence
Clinical Pathology
Urinary Tract
Disease Progression
Regression Analysis
Neoplasm Metastasis
Carcinoma
Mortality
Therapeutics

Keywords

  • Architecture
  • Recurrence
  • Survival
  • Urinary tract cancer
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Urology

Cite this

Tumour architecture is an independent predictor of outcomes after nephroureterectomy : A multi-institutional analysis of 1363 patients. / Remzi, Mesut; Haitel, Andrea; Margulis, Vitaly; Karakiewizc, Pierre; Montorsi, Francesco; Kikuchi, Eiji; Zigeuner, Richard; Weizer, Alon; Bolenz, Christian; Bensalah, Karim; Suardi, Nazareno; Raman, Jay D.; Lotan, Yair; Waldert, Matthias; Ng, Casey K.; Fernández, Mario; Koppie, Theresa M.; Ströbel, Philipp; Kabbani, Wareef; Murai, Masaru; Langner, Cord; Roscigno, Marco; Wheat, Jeffrey; Guo, Charles C.; Wood, Christopher G.; Shariat, Shahrokh F.

In: BJU International, Vol. 103, No. 3, 02.2009, p. 307-311.

Research output: Contribution to journalArticle

Remzi, M, Haitel, A, Margulis, V, Karakiewizc, P, Montorsi, F, Kikuchi, E, Zigeuner, R, Weizer, A, Bolenz, C, Bensalah, K, Suardi, N, Raman, JD, Lotan, Y, Waldert, M, Ng, CK, Fernández, M, Koppie, TM, Ströbel, P, Kabbani, W, Murai, M, Langner, C, Roscigno, M, Wheat, J, Guo, CC, Wood, CG & Shariat, SF 2009, 'Tumour architecture is an independent predictor of outcomes after nephroureterectomy: A multi-institutional analysis of 1363 patients', BJU International, vol. 103, no. 3, pp. 307-311. https://doi.org/10.1111/j.1464-410X.2008.08003.x
Remzi, Mesut ; Haitel, Andrea ; Margulis, Vitaly ; Karakiewizc, Pierre ; Montorsi, Francesco ; Kikuchi, Eiji ; Zigeuner, Richard ; Weizer, Alon ; Bolenz, Christian ; Bensalah, Karim ; Suardi, Nazareno ; Raman, Jay D. ; Lotan, Yair ; Waldert, Matthias ; Ng, Casey K. ; Fernández, Mario ; Koppie, Theresa M. ; Ströbel, Philipp ; Kabbani, Wareef ; Murai, Masaru ; Langner, Cord ; Roscigno, Marco ; Wheat, Jeffrey ; Guo, Charles C. ; Wood, Christopher G. ; Shariat, Shahrokh F. / Tumour architecture is an independent predictor of outcomes after nephroureterectomy : A multi-institutional analysis of 1363 patients. In: BJU International. 2009 ; Vol. 103, No. 3. pp. 307-311.
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AU - Remzi, Mesut

AU - Haitel, Andrea

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AU - Karakiewizc, Pierre

AU - Montorsi, Francesco

AU - Kikuchi, Eiji

AU - Zigeuner, Richard

AU - Weizer, Alon

AU - Bolenz, Christian

AU - Bensalah, Karim

AU - Suardi, Nazareno

AU - Raman, Jay D.

AU - Lotan, Yair

AU - Waldert, Matthias

AU - Ng, Casey K.

AU - Fernández, Mario

AU - Koppie, Theresa M.

AU - Ströbel, Philipp

AU - Kabbani, Wareef

AU - Murai, Masaru

AU - Langner, Cord

AU - Roscigno, Marco

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AU - Wood, Christopher G.

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N2 - OBJECTIVE: To assess whether tumour architecture can help to refine the prognosis of patients treated with nephroureterectomy (NU) for urothelial carcinoma (UC) of the upper urinary tract (UT), as the prognostic value of tumour architecture (papillary vs sessile) in UTUC remains elusive. PATIENTS AND METHODS: The study included 1363 patients with UTUC and treated with radical NU at 12 centres worldwide. All slides were re-reviewed according to strict criteria by genitourinary pathologists who were unaware of the findings of the original pathology slides and clinical outcomes. Gross tumour architecture was categorized as sessile vs papillary. RESULTS: Papillary growth was identified in 983 patients (72.2%) and sessile growth in 380 (27.8%). The sessile growth pattern was associated with higher tumour grade, more advanced stage, lymphovascular invasion, and metastasis to lymph nodes (all P < 0.001). In multivariable Cox regression analyses that adjusted for the effects of pathological stage, grade and lymph node status, tumour architecture (sessile or papillary) was an independent predictor of cancer recurrence (hazard ratio 1.5, P = 0.002) and cancer-specific mortality (1.6, P = 0.001). Adding tumour architecture increased the predictive accuracy of a model that comprised pathological stage, grade and lymph node status for predicting cancer recurrence and cancer-specific death by a minimal but statistically significant margin (gain in predictive accuracy 1% and 0.5%, both P < 0.001). CONCLUSION: The tumour architecture of UTUC is associated with established features of biologically aggressive disease, and more importantly, with prognosis after radical NU. Including tumour architecture in predictive models for disease progression should be considered, aiming to identify patients who might benefit from early systemic therapeutic intervention.

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