Two acidic polysaccharides having reticuloendothelial system-potentiating activity from the raw root of Rehmannia glutinosa

M. Tomoda, H. Miyamoto, N. Shimizu, R. Gonda, N. Ohara

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Abstract

Two acidic polysaccharides, called rehmannan FS-I and rehmannan FS-II, were isolated from the raw root of Rehmannia glutinosa LIBOSCHITZ. They were homogeneous on electrophoresis and gel chromatography, and their molecular masses were estimated to be 5.8 x 104 and 6.6 x 104, respectively. Rehmannan FS-I is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid: D-glucuronic acid in the molar ratio of 68:40:4:84:3; rehmannan FS-IT is composed of L-arabinose: D-galactose: L-rhamnose: D-galacturonic acid in the molar ratio of 18:15:4:33, in addition to small amounts of O-acetyl groups. About two-thirds (rehmannan FS-I) and about one half (rehmannan FS-II) of the hexuronic acid residues exist as methyl esters. Methylation analysis of the carboxyl-reduced derivatives and nuclear magnetic resonance studies indicated that their structural features include mainly both arabino-3,6-galactan and rhamno-galacturonan type structural units. Both polysaccharides showed remarkable reticuloendothelial system-potentiating activity in a carbon clearance test.

Original languageEnglish
Pages (from-to)1456-1459
Number of pages4
JournalBiological and Pharmaceutical Bulletin
Volume17
Issue number11
Publication statusPublished - 1994
Externally publishedYes

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Keywords

  • Acidic arabinogalactan
  • Immunological activity
  • Polysaccharides structure
  • Rehmannan FS-I
  • Rehmannan FS-II
  • Rehmannia glutinosa

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

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