Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels

Yoshifumi Saisho; Fumitake Saitoh; Mitsuhisa Tabata; Toshio Imafuku; Tohru Ogihara; Ikuko Issiki; Yukio Hattori; Yasuhiro Yamashiro

doi:10.2169/internalmedicine.42.595

Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels

Yoshifumi Saisho, Fumitake Saitoh, Mitsuhisa Tabata, Toshio Imafuku, Tohru Ogihara, Ikuko Issiki, Yukio Hattori, Yasuhiro Yamashiro

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.

Original language	English
Pages (from-to)	595-598
Number of pages	4
Journal	Internal Medicine
Volume	42
Issue number	7
DOIs	https://doi.org/10.2169/internalmedicine.42.595
Publication status	Published - 2003 Jul 1
Externally published	Yes

Keywords

HbA
Hemoglobinopathy
High-performance liquid chromatography (HPLC)

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.42.595

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abstract = "We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.",

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AU - Saisho, Yoshifumi

AU - Saitoh, Fumitake

AU - Tabata, Mitsuhisa

AU - Imafuku, Toshio

AU - Ogihara, Tohru

AU - Issiki, Ikuko

AU - Hattori, Yukio

AU - Yamashiro, Yasuhiro

PY - 2003/7/1

Y1 - 2003/7/1

N2 - We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.

AB - We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.

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KW - Hemoglobinopathy

KW - High-performance liquid chromatography (HPLC)

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Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels

Abstract

Keywords

ASJC Scopus subject areas

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