Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels

Yoshifumi Saisho, Fumitake Saitoh, Mitsuhisa Tabata, Toshio Imafuku, Tohru Ogihara, Ikuko Issiki, Yukio Hattori, Yasuhiro Yamashiro

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1 Citation (Scopus)


We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.

Original languageEnglish
Pages (from-to)595-598
Number of pages4
JournalInternal Medicine
Issue number7
Publication statusPublished - 2003 Jul 1
Externally publishedYes



  • HbA
  • Hemoglobinopathy
  • High-performance liquid chromatography (HPLC)

ASJC Scopus subject areas

  • Internal Medicine

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