Abstract
We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.
| Original language | English |
|---|---|
| Pages (from-to) | 595-598 |
| Number of pages | 4 |
| Journal | Internal Medicine |
| Volume | 42 |
| Issue number | 7 |
| Publication status | Published - 2003 Jul 1 |
| Externally published | Yes |
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Keywords
- HbA
- Hemoglobinopathy
- High-performance liquid chromatography (HPLC)
ASJC Scopus subject areas
- Internal Medicine
Cite this
Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels. / Saisho, Yoshifumi; Saitoh, Fumitake; Tabata, Mitsuhisa; Imafuku, Toshio; Ogihara, Tohru; Issiki, Ikuko; Hattori, Yukio; Yamashiro, Yasuhiro.
In: Internal Medicine, Vol. 42, No. 7, 01.07.2003, p. 595-598.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two cases in which an abnormal hemoglobin (Hb Kamakura) was identified on the basis of an abnormally low glycohemoglobin levels
AU - Saisho, Yoshifumi
AU - Saitoh, Fumitake
AU - Tabata, Mitsuhisa
AU - Imafuku, Toshio
AU - Ogihara, Tohru
AU - Issiki, Ikuko
AU - Hattori, Yukio
AU - Yamashiro, Yasuhiro
PY - 2003/7/1
Y1 - 2003/7/1
N2 - We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.
AB - We encountered two patients with abnormally low glycohemoglobin levels in spite of normal plasma glucose levels. Since the presence of an abnormal hemoglobin was suggested by high-performance liquid chromatography (HPLC), gene analysis of these two patients was conducted by single-strand conformation polymorphism (SSCP) analysis followed by direct sequencing, and Hb Kamakura with one base substitution (β3 Leu→Val) in the β globin gene was detected in both patients. There has been only one report of Hb Kamakura in Kanagawa Prefecture, and our patients represent the second and third cases, respectively.
KW - HbA
KW - Hemoglobinopathy
KW - High-performance liquid chromatography (HPLC)
UR - http://www.scopus.com/inward/record.url?scp=0043173818&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0043173818&partnerID=8YFLogxK
M3 - Article
C2 - 12879953
AN - SCOPUS:0043173818
VL - 42
SP - 595
EP - 598
JO - Internal Medicine
JF - Internal Medicine
SN - 0918-2918
IS - 7
ER -