Two cases in which isosorbide dinitrate and calcium antagonist benidipine were effective against life threatening coronary vasospasm

Toshihisa Anzai, Daihiko Hakuno, Akio Kawamura, Tsutomu Yoshikawa, Satoshi Ogawa

Research output: Contribution to journalArticle


Sudden cardiac death caused by coronary vasospasm still remains a serious problem. We present two rare cases involving an initial coronary vasospasm which caused acute myocardial infarction (AMI) and ventricular fibrillation. Both cases were well controlled by isosorbide dinitrate and benidipine, a calcium antagonist. One case experienced AMI while undergoing the therapy of the calcium antagonist amlodipine. We should consider this antispastic characteristic when selecting a calcium antagonist to prevent sudden cardiac death.

Original languageEnglish
Pages (from-to)1381-1385
Number of pages5
JournalRespiration and Circulation
Issue number12
Publication statusPublished - 2007 Dec 1



  • Calcium antagonist
  • Coronary vasospasm
  • Sudden cardiac death

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

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