Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy

Atsushi Iwama; Akiyoshi Miwa; Toshiyuki Suzuki; Norio Komatsu; Minora Yoshida; Toshio Suda; Shinobu Sakamoto; Yasusada Miura

doi:10.2169/internalmedicine.31.214

Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy

Atsushi Iwama, Akiyoshi Miwa, Toshiyuki Suzuki, Norio Komatsu, Minora Yoshida, Toshio Suda, Shinobu Sakamoto, Yasusada Miura

The Sakaguchi Laboratory of Developmental Biology Department of Cell Differentiation

Research output: Contribution to journal › Article › peer-review

Abstract

Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M_5b with trilineage myelodysplasia and Case 2: M₄ with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.

Original language	English
Pages (from-to)	214-217
Number of pages	4
Journal	Internal Medicine
Volume	31
Issue number	2
DOIs	https://doi.org/10.2169/internalmedicine.31.214
Publication status	Published - 1992 Jan 1

Keywords

acute transformation
myelodysplasia

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.31.214

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title = "Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy",

abstract = "Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M5b with trilineage myelodysplasia and Case 2: M4 with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.",

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AU - Iwama, Atsushi

AU - Miwa, Akiyoshi

AU - Suzuki, Toshiyuki

AU - Komatsu, Norio

AU - Yoshida, Minora

AU - Suda, Toshio

AU - Sakamoto, Shinobu

AU - Miura, Yasusada

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N2 - Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M5b with trilineage myelodysplasia and Case 2: M4 with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.

AB - Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M5b with trilineage myelodysplasia and Case 2: M4 with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.

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Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy

Abstract

Keywords

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