Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy

Atsushi Iwama, Akiyoshi Miwa, Toshiyuki Suzuki, Norio Komatsu, Minora Yoshida, Toshio Suda, Shinobu Sakamoto, Yasusada Miura

Research output: Contribution to journalArticle

Abstract

Two patients with acute myeloid leukemia (AML) developed a chronic myelomonocytic leukemia (CMMoL)-like state after chemotherapy. Both patients showed morphological evidence of myelodysplasia together with acute leukemia at presentation (Case 1: M5b with trilineage myelodysplasia and Case 2: M4 with dysmegakaryocytopoiesis). They also showed persistent monocytosis without prominent blast cell proliferation after induction therapy. The possibility was suggested that these two patients were in acute transformation from CMMoL at presentation and returned to a CMMoL-like state after induction therapy.

Original languageEnglish
Pages (from-to)214-217
Number of pages4
JournalInternal Medicine
Volume31
Issue number2
DOIs
Publication statusPublished - 1992 Jan 1

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Keywords

  • acute transformation
  • myelodysplasia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Iwama, A., Miwa, A., Suzuki, T., Komatsu, N., Yoshida, M., Suda, T., Sakamoto, S., & Miura, Y. (1992). Two Cases of Acute Myeloid Leukemia Evolving into a Chronic Myelomonocytic Leukemia-like State after Induction Therapy. Internal Medicine, 31(2), 214-217. https://doi.org/10.2169/internalmedicine.31.214