Two cases of classical polyarteritis nodosa associated with MPO-ANCA

Masami Tanaka, Koichi Matsuo, Hiroshi Nakamura, Shinsuke Ishikawa, Kimihiko Matsuyama

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Case 1: An 82-year-old female had a drop-foot, livedo reticularis and paresthesia. MPO-ANCA was positive. Because of developing renal dysfunction, she underwent steroid pulse therapy and dialysis, but died from the complication of congestive heart failure. Autopsy revealed necrotizing arteritis in the interlobular arteries and the arcuate arteries of the kidneys. Crescent formation was not found in the glomeruli. Case 2: A 49-year-old male had a drop-foot and numbness. MPO-ANCA was positive. Because of developing renal failure, he underwent dialysis and steroid pulse therapy. MPO-ANCA became negative. Nevertheless, he developed perforation of multiple ulcers in the small intestine and died. Pathohistology revealed arteritis in medium-size arteries at the branch level of the mesenteric arteries. Since the presented two cases showed rapidly and irreversibly aggravated renal function with positive MPO-ANCA, MPA was suspected. However, pathological findings from the autopsy and operation and not the kidney biopsy supported the diagnosis of polyarteritis nodcsa(PN). Vasculitis in the arterioles was absent. MPO-ANCA is not specific, and it can be detected in not only MPA, but also PN. The clinical course and pathological findings must be considered to differentiate PN from MPA.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalJapanese Journal of Nephrology
Volume48
Issue number4
Publication statusPublished - 2006 Jul 6
Externally publishedYes

Fingerprint

Polyarteritis Nodosa
Antineutrophil Cytoplasmic Antibodies
Kidney
Arteries
Foot
Dialysis
Autopsy
Livedo Reticularis
Steroids
Arteritis
Mesenteric Arteries
Hypesthesia
Paresthesia
Arterioles
Vasculitis
Small Intestine
Ulcer
Renal Insufficiency
Heart Failure
Biopsy

Keywords

  • Microscopic polyangiitis
  • MPO-ANCA
  • Polyarteritis nodosa

ASJC Scopus subject areas

  • Nephrology

Cite this

Tanaka, M., Matsuo, K., Nakamura, H., Ishikawa, S., & Matsuyama, K. (2006). Two cases of classical polyarteritis nodosa associated with MPO-ANCA. Japanese Journal of Nephrology, 48(4), 371-376.

Two cases of classical polyarteritis nodosa associated with MPO-ANCA. / Tanaka, Masami; Matsuo, Koichi; Nakamura, Hiroshi; Ishikawa, Shinsuke; Matsuyama, Kimihiko.

In: Japanese Journal of Nephrology, Vol. 48, No. 4, 06.07.2006, p. 371-376.

Research output: Contribution to journalArticle

Tanaka, M, Matsuo, K, Nakamura, H, Ishikawa, S & Matsuyama, K 2006, 'Two cases of classical polyarteritis nodosa associated with MPO-ANCA', Japanese Journal of Nephrology, vol. 48, no. 4, pp. 371-376.
Tanaka M, Matsuo K, Nakamura H, Ishikawa S, Matsuyama K. Two cases of classical polyarteritis nodosa associated with MPO-ANCA. Japanese Journal of Nephrology. 2006 Jul 6;48(4):371-376.
Tanaka, Masami ; Matsuo, Koichi ; Nakamura, Hiroshi ; Ishikawa, Shinsuke ; Matsuyama, Kimihiko. / Two cases of classical polyarteritis nodosa associated with MPO-ANCA. In: Japanese Journal of Nephrology. 2006 ; Vol. 48, No. 4. pp. 371-376.
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