Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Yoshinori Nakagawa A; Akira Shimada; Yoichi Oikawa; Jun Ichiro Irie; Toshkatsu Shigihara; Kazuhiro Tsumura; Shosaku Narumi; Takao Saruta

doi:10.1196/annals.1288.059

Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Yoshinori Nakagawa A, Akira Shimada, Yoichi Oikawa, Jun Ichiro Irie, Toshkatsu Shigihara, Kazuhiro Tsumura, Shosaku Narumi, Takao Saruta

Department of Internal Medicine (Nephrology, Endocrinology and Metabolism)

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4⁺ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

Original language	English
Pages (from-to)	359-361
Number of pages	3
Journal	Annals of the New York Academy of Sciences
Volume	1005
DOIs	https://doi.org/10.1196/annals.1288.059
Publication status	Published - 2003

Keywords

Fulminant type 1 diabetes mellitus
Glutamic acid decarboxylase (GAD)
Interferon-inducible protein-10 (IP-10)

ASJC Scopus subject areas

Neuroscience(all)
Biochemistry, Genetics and Molecular Biology(all)
History and Philosophy of Science

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1196/annals.1288.059

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abstract = "Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable {"}islet-associated{"} autoantibody, so it was originally proposed as being {"}nonautoimmune-mediated{"}; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.",

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T1 - Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

AU - Nakagawa A, Yoshinori

AU - Shimada, Akira

AU - Oikawa, Yoichi

AU - Irie, Jun Ichiro

AU - Shigihara, Toshkatsu

AU - Tsumura, Kazuhiro

AU - Narumi, Shosaku

AU - Saruta, Takao

PY - 2003

Y1 - 2003

N2 - Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

AB - Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

KW - Fulminant type 1 diabetes mellitus

KW - Glutamic acid decarboxylase (GAD)

KW - Interferon-inducible protein-10 (IP-10)

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JO - Annals of the New York Academy of Sciences

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Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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