Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity

Yoshinori Nakagawa A, Akira Shimada, Yoichi Oikawa, Junichiro Irie, Toshkatsu Shigihara, Kazuhiro Tsumura, Shosaku Narumi, Takao Saruta

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Recently, a novel subtype of type 1 diabetes, so-called fulminant type 1 diabetes, has been proposed. One of the characteristics of this subtype is the absence of detectable "islet-associated" autoantibody, so it was originally proposed as being "nonautoimmune-mediated"; however, it has not yet been concluded whether autoimmunity is involved. We have previously shown that serum interferon-inducible protein-10 and glutamic acid decarboxylase-reactive CD4+ interferon-γ-producing cells in the peripheral blood are good markers for T cell-mediated autoimmunity in type 1 diabetes. Here, we report two cases of fulminant type 1 diabetes in which these markers were detected and in which the involvement of islet-associated autoimmunity is suggested.

Original languageEnglish
Pages (from-to)359-361
Number of pages3
JournalAnnals of the New York Academy of Sciences
Volume1005
DOIs
Publication statusPublished - 2003

Fingerprint

Medical problems
Autoimmunity
Type 1 Diabetes Mellitus
Chemokine CXCL10
Glutamate Decarboxylase
T-cells
Autoantibodies
Interferons
Blood
T-Lymphocytes
Diabetes
Serum
Cells

Keywords

  • Fulminant type 1 diabetes mellitus
  • Glutamic acid decarboxylase (GAD)
  • Interferon-inducible protein-10 (IP-10)

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity. / Nakagawa A, Yoshinori; Shimada, Akira; Oikawa, Yoichi; Irie, Junichiro; Shigihara, Toshkatsu; Tsumura, Kazuhiro; Narumi, Shosaku; Saruta, Takao.

In: Annals of the New York Academy of Sciences, Vol. 1005, 2003, p. 359-361.

Research output: Contribution to journalArticle

Nakagawa A, Y, Shimada, A, Oikawa, Y, Irie, J, Shigihara, T, Tsumura, K, Narumi, S & Saruta, T 2003, 'Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity', Annals of the New York Academy of Sciences, vol. 1005, pp. 359-361. https://doi.org/10.1196/annals.1288.059
Nakagawa A, Yoshinori ; Shimada, Akira ; Oikawa, Yoichi ; Irie, Junichiro ; Shigihara, Toshkatsu ; Tsumura, Kazuhiro ; Narumi, Shosaku ; Saruta, Takao. / Two cases of "fulminant" type 1 diabetes suggesting involvement of autoimmunity. In: Annals of the New York Academy of Sciences. 2003 ; Vol. 1005. pp. 359-361.
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