Two cases of neuroblastoma comprising two distinct clones

Fumito Yamazaki; Atsuko Nakazawa; Tomoo Osumi; Naoki Shimojima; Takeo Tanaka; Akira Nakagawara; Hiroyuki Shimada

doi:10.1002/pbc.24779

Two cases of neuroblastoma comprising two distinct clones

Fumito Yamazaki, Atsuko Nakazawa, Tomoo Osumi, Naoki Shimojima, Takeo Tanaka, Akira Nakagawara, Hiroyuki Shimada

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

We report two cases of high-risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but also in MYCN amplification and HA-RAS/TRKA immunoreactivity (Case 1), anaplastic lymphoma kinase (ALK) immunoreactivity (Case 2). These two cases with multiple separated components were similar to cases classified as ganglioneuroblastoma, nodular subtype (GNBn), in terms of composite tumor. Comparable to the GNBn category, the prognosis of the patients described here may depend on the components with unfavorable histology according to International Neuroblastoma Pathology Classification. Further analyses of such composite neuroblastoma cases are important for assessing disease prognosis.

Original language	English
Pages (from-to)	760-762
Number of pages	3
Journal	Pediatric Blood and Cancer
Volume	61
Issue number	4
DOIs	https://doi.org/10.1002/pbc.24779
Publication status	Published - 2014 Apr

Keywords

Ganglioneuroblastoma
International neuroblastoma pathology classification
Neuroblastoma

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.24779

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abstract = "We report two cases of high-risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but also in MYCN amplification and HA-RAS/TRKA immunoreactivity (Case 1), anaplastic lymphoma kinase (ALK) immunoreactivity (Case 2). These two cases with multiple separated components were similar to cases classified as ganglioneuroblastoma, nodular subtype (GNBn), in terms of composite tumor. Comparable to the GNBn category, the prognosis of the patients described here may depend on the components with unfavorable histology according to International Neuroblastoma Pathology Classification. Further analyses of such composite neuroblastoma cases are important for assessing disease prognosis.",

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AU - Yamazaki, Fumito

AU - Nakazawa, Atsuko

AU - Osumi, Tomoo

AU - Shimojima, Naoki

AU - Tanaka, Takeo

AU - Nakagawara, Akira

AU - Shimada, Hiroyuki

PY - 2014/4

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AB - We report two cases of high-risk metastatic neuroblastoma, comprising two biologically distinct components in the adrenal primary tumor, which showed clear differences not only histologically but also in MYCN amplification and HA-RAS/TRKA immunoreactivity (Case 1), anaplastic lymphoma kinase (ALK) immunoreactivity (Case 2). These two cases with multiple separated components were similar to cases classified as ganglioneuroblastoma, nodular subtype (GNBn), in terms of composite tumor. Comparable to the GNBn category, the prognosis of the patients described here may depend on the components with unfavorable histology according to International Neuroblastoma Pathology Classification. Further analyses of such composite neuroblastoma cases are important for assessing disease prognosis.

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Two cases of neuroblastoma comprising two distinct clones

Abstract

Keywords

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