Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

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3 Citations (Scopus)

Abstract

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma (PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

Original languageEnglish
Pages (from-to)9222-9228
Number of pages7
JournalWorld Journal of Gastroenterology
Volume22
Issue number41
DOIs
Publication statusPublished - 2016 Nov 7

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Adenocarcinoma
Neoplasm Metastasis
Pancreatectomy
Pancreatic Neoplasms
Pancreas
Neoplasms

Keywords

  • Carcinogenesis
  • Carcinoma
  • Neoplasm micrometastasis
  • Pancreatic ductal
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

Cite this

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title = "Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis",
abstract = "There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma (PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.",
keywords = "Carcinogenesis, Carcinoma, Neoplasm micrometastasis, Pancreatic ductal, Recurrence",
author = "Yusuke Fujita and Minoru Kitago and Yohei Masugi and Osamu Itano and Masahiro Shinoda and Yuta Abe and Taizo Hibi and Hiroshi Yagi and Yoko Nishimura and Michiie Sakamoto and Yuukou Kitagawa",
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AU - Fujita, Yusuke

AU - Kitago, Minoru

AU - Masugi, Yohei

AU - Itano, Osamu

AU - Shinoda, Masahiro

AU - Abe, Yuta

AU - Hibi, Taizo

AU - Yagi, Hiroshi

AU - Nishimura, Yoko

AU - Sakamoto, Michiie

AU - Kitagawa, Yuukou

PY - 2016/11/7

Y1 - 2016/11/7

N2 - There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma (PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

AB - There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma (PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

KW - Carcinogenesis

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KW - Neoplasm micrometastasis

KW - Pancreatic ductal

KW - Recurrence

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