Two cases of pancreatic ductal adenocarcinoma with intrapancreatic metastasis

Yusuke Fujita, Minoru Kitago, Yohei Masugi, Osamu Itano, Masahiro Shinoda, Yuta Abe, Taizo Hibi, Hiroshi Yagi, Yoko Fujii-Nishimura, Michiie Sakamoto, Yuko Kitagawa

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

There are no standardized diagnostic criteria for intrapancreatic metastasis of pancreatic ductal adenocarcinoma (PDAC). Here, we report two cases of patients with PDAC who were pathologically diagnosed as harboring intrapancreatic metastasis. In both cases, the main lesions were located in the pancreatic body, and no other lesion was detected preoperatively. The patients were diagnosed with pancreatic body cancers and distal pancreatectomy was performed. Pathological findings revealed microscopic cancer nests, which had connections to neither the main lesion nor the premalignant lesion in the pancreatic tail parenchyma. In both cases, the histological type of the daughter lesion was quite similar to that of the main lesion. Hence, we diagnosed the daughter lesions as metastatic foci in the pancreas. Although intrapancreatic metastasis of PDAC has been regarded as a poor prognostic factor, few reports of intrapancreatic metastasis are available. This article reports two such cases and provides a review of the literature.

Original languageEnglish
Pages (from-to)9222-9228
Number of pages7
JournalWorld Journal of Gastroenterology
Volume22
Issue number41
DOIs
Publication statusPublished - 2016 Nov 7

Keywords

  • Carcinogenesis
  • Carcinoma
  • Neoplasm micrometastasis
  • Pancreatic ductal
  • Recurrence

ASJC Scopus subject areas

  • Gastroenterology

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