Two Cases of Pathological Complete Response to Neoadjuvant Chemoradiation Therapy in Pancreatic Cancer

Yoko Fujii-Nishimura, Ryo Nishiyama, Minoru Kitago, Yohei Masugi, Akihisa Ueno, Koichi Aiura, Shigeyuki Kawachi, Miho Kawaida, Yuta Abe, Masahiro Shinoda, Osamu Itano, Akihiro Tanimoto, Michiie Sakamoto, Yuko Kitagawa

Research output: Contribution to journalArticle

Abstract

Neoadjuvant chemoradiation therapy (NACRT) is increasingly used in patients with a potentially or borderline resectable pancreatic ductal adenocarcinoma (PDA) and it has been shown to improve survival and reduce locoregional metastatic disease. It is rare for patients with PDA to have a pathological complete response (pCR) to NACRT, but such patients reportedly have a good prognosis. We report the clinicopathological findings of two cases of pCR to NACRT in PDA. Both patients underwent pancreatectomy after NACRT (5-fluorouracil, mitomycin C, cisplatin, and radiation). Neither had residual invasive carcinoma and both showed extensive fibrotic regions with several ducts regarded as having pancreatic intraepithelial neoplasia 3/carcinoma in situ in their post-therapy specimens. It is noteworthy that both patients had a history of a second primary cancer. They both had comparatively good outcomes: one lived for 9 years after the initial pancreatectomy and the other is still alive without recurrence after 2 years.

Original languageEnglish
Pages (from-to)26-31
Number of pages6
JournalThe Keio journal of medicine
Volume64
Issue number2
DOIs
Publication statusPublished - 2015

ASJC Scopus subject areas

  • Medicine(all)

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    Fujii-Nishimura, Y., Nishiyama, R., Kitago, M., Masugi, Y., Ueno, A., Aiura, K., Kawachi, S., Kawaida, M., Abe, Y., Shinoda, M., Itano, O., Tanimoto, A., Sakamoto, M., & Kitagawa, Y. (2015). Two Cases of Pathological Complete Response to Neoadjuvant Chemoradiation Therapy in Pancreatic Cancer. The Keio journal of medicine, 64(2), 26-31. https://doi.org/10.2302/kjm.2014-0014-CR