Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies

S. Satoh, Michito Hirakata, K. Nakamura, M. Kuwana, Y. Ohosone, Y. Matsuoka, S. Irimajiri, J. Fukuda, S. Kuramochi, T. Mimori, Y. Ikeda

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Abstract

We present two cases of polymyositis (PM) associated with interstitial pneumonia (IP) whose sera contain autoantibodies to OJ (isoleucyl tRNA synthetase). The first patient is a 51 year-old female who was diagnosed as rheumatoid arthritis (RA) and treated with gold and corticosteroid at another hospital. She was admitted to Keio University Hospital due to worsening of dyspnea on exertion and polyarthritis. Laboratory findings revealed elevation of serum CK and LDH. A diagnosis of PM was made based on the myogenic pattern of EMG and pathological feature by muscle biopsy. Chest radiography and CT showed interstitial fibrosis. Because of clinical deterioration, the dose of corticosteroid was increased (prednisolone 50 mg/day) and her symptom was stabilized. The second patient, a 62 year-old male, was admitted to Kawasaki Municipal Hospital because of dyspnea on exertion, polyarthritis, and fever. He was diagnosed as PM associated with IP on the basis of his clinical and laboratory findings, and chest radiography. He was treated with methylprednisolone pulse therapy (800 mg/day for three days) and his symptoms were improved. Both patients were found to have autoantibodies to the OJ. Autoantibodies to aminoacyl tRNA synthetase have been described to be associated with myositis and/or IP. In North America, it was reported that all patients with anti-OJ had either myositis or IP or both. This suggests that anti-OJ was commonly associated with the anti-synthetase syndrome observed with other anti-synthetases. This is the first report of Japanese patients with anti-OJ antibody. The clinical features of these patients were likely to be similar to those observed in North American patients. However, further studies are necessary to clarify the precise clinical significance of this antibody.

Original languageEnglish
Pages (from-to)534-541
Number of pages8
JournalRyumachi
Volume38
Issue number3
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Isoleucine-tRNA Ligase
Polymyositis
Interstitial Lung Diseases
Antibodies
Autoantibodies
Myositis
Ligases
Radiography
Dyspnea
Arthritis
Adrenal Cortex Hormones
Thorax
Municipal Hospitals
Amino Acyl-tRNA Synthetases
Methylprednisolone
North America
Prednisolone
Serum
Gold
Anti-Idiotypic Antibodies

Keywords

  • Aminoacyl-tRNA synthetase
  • Interstitial pneumonia
  • Polymyositis/dermatomyositis

ASJC Scopus subject areas

  • Rheumatology

Cite this

Satoh, S., Hirakata, M., Nakamura, K., Kuwana, M., Ohosone, Y., Matsuoka, Y., ... Ikeda, Y. (1998). Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies. Ryumachi, 38(3), 534-541.

Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies. / Satoh, S.; Hirakata, Michito; Nakamura, K.; Kuwana, M.; Ohosone, Y.; Matsuoka, Y.; Irimajiri, S.; Fukuda, J.; Kuramochi, S.; Mimori, T.; Ikeda, Y.

In: Ryumachi, Vol. 38, No. 3, 1998, p. 534-541.

Research output: Contribution to journalArticle

Satoh, S, Hirakata, M, Nakamura, K, Kuwana, M, Ohosone, Y, Matsuoka, Y, Irimajiri, S, Fukuda, J, Kuramochi, S, Mimori, T & Ikeda, Y 1998, 'Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies', Ryumachi, vol. 38, no. 3, pp. 534-541.
Satoh, S. ; Hirakata, Michito ; Nakamura, K. ; Kuwana, M. ; Ohosone, Y. ; Matsuoka, Y. ; Irimajiri, S. ; Fukuda, J. ; Kuramochi, S. ; Mimori, T. ; Ikeda, Y. / Two cases of polymyositis associated with interstitial pneumonia with anti-OJ (isoleucyl tRNA synthetase) antibodies. In: Ryumachi. 1998 ; Vol. 38, No. 3. pp. 534-541.
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abstract = "We present two cases of polymyositis (PM) associated with interstitial pneumonia (IP) whose sera contain autoantibodies to OJ (isoleucyl tRNA synthetase). The first patient is a 51 year-old female who was diagnosed as rheumatoid arthritis (RA) and treated with gold and corticosteroid at another hospital. She was admitted to Keio University Hospital due to worsening of dyspnea on exertion and polyarthritis. Laboratory findings revealed elevation of serum CK and LDH. A diagnosis of PM was made based on the myogenic pattern of EMG and pathological feature by muscle biopsy. Chest radiography and CT showed interstitial fibrosis. Because of clinical deterioration, the dose of corticosteroid was increased (prednisolone 50 mg/day) and her symptom was stabilized. The second patient, a 62 year-old male, was admitted to Kawasaki Municipal Hospital because of dyspnea on exertion, polyarthritis, and fever. He was diagnosed as PM associated with IP on the basis of his clinical and laboratory findings, and chest radiography. He was treated with methylprednisolone pulse therapy (800 mg/day for three days) and his symptoms were improved. Both patients were found to have autoantibodies to the OJ. Autoantibodies to aminoacyl tRNA synthetase have been described to be associated with myositis and/or IP. In North America, it was reported that all patients with anti-OJ had either myositis or IP or both. This suggests that anti-OJ was commonly associated with the anti-synthetase syndrome observed with other anti-synthetases. This is the first report of Japanese patients with anti-OJ antibody. The clinical features of these patients were likely to be similar to those observed in North American patients. However, further studies are necessary to clarify the precise clinical significance of this antibody.",
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AB - We present two cases of polymyositis (PM) associated with interstitial pneumonia (IP) whose sera contain autoantibodies to OJ (isoleucyl tRNA synthetase). The first patient is a 51 year-old female who was diagnosed as rheumatoid arthritis (RA) and treated with gold and corticosteroid at another hospital. She was admitted to Keio University Hospital due to worsening of dyspnea on exertion and polyarthritis. Laboratory findings revealed elevation of serum CK and LDH. A diagnosis of PM was made based on the myogenic pattern of EMG and pathological feature by muscle biopsy. Chest radiography and CT showed interstitial fibrosis. Because of clinical deterioration, the dose of corticosteroid was increased (prednisolone 50 mg/day) and her symptom was stabilized. The second patient, a 62 year-old male, was admitted to Kawasaki Municipal Hospital because of dyspnea on exertion, polyarthritis, and fever. He was diagnosed as PM associated with IP on the basis of his clinical and laboratory findings, and chest radiography. He was treated with methylprednisolone pulse therapy (800 mg/day for three days) and his symptoms were improved. Both patients were found to have autoantibodies to the OJ. Autoantibodies to aminoacyl tRNA synthetase have been described to be associated with myositis and/or IP. In North America, it was reported that all patients with anti-OJ had either myositis or IP or both. This suggests that anti-OJ was commonly associated with the anti-synthetase syndrome observed with other anti-synthetases. This is the first report of Japanese patients with anti-OJ antibody. The clinical features of these patients were likely to be similar to those observed in North American patients. However, further studies are necessary to clarify the precise clinical significance of this antibody.

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