Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus

K. Naoki, M. Oosumi, T. Takasugi, T. Toyoda, T. Kawashiro, T. Aoyagi

Research output: Contribution to journalArticle

Abstract

We encountered two cases of pulmonary disease caused by M. chelonae subsp. abscessus. [Case 1] A 72-year-old man was admitted to the hospital because of fever. He had been observed for one year after being given a diagnosis of pulmonary disease caused by Myocobacterium avium complex. Sputum examination revealed acid-fast bacilli (Gaffky 9). He recovered after administration of clarithromycin (CAM) and other drugs. [Case 2] A 61-year- old man was admitted to the hospital because of coughing and sputum production. He had been observed for 4 years after being given a diagnosis of pulmonary M. fortuitum disease. Sputum examination revealed acid-fast bacilli (Gaffky 7). His symptoms deteriorated even though he received anti- tuberculosis agents and CAM. After measurement of minimal inhibitory concentration (MIC), he was given amikacin (AMK). In both cases, the bacilli found in sputum obtained on admission were identified as M. chelonae subsp. abscessus by DNA hybridization. They were completely resistant to all anti- tuberculosis agents. However, the disk method show that they were sensitive to AMK, imipenem and CAM. The MIC value of those strains to CAM was 0.78 μg/ml in case 1 and more than 100 μg/ml in case 2. The results obtained by MIC measurement were consistent with the clinical outcome. AMK, cefoxitin (CFX), and CAM had been used to treat M. chelonae subsp. abscessus in Europe, but the MIC value differed from strain to strain within a species. Thus the present data suggest that measurement of the MIC value of CAM would be necessary to predict its therapeutic effect.

Original languageEnglish
Pages (from-to)1264-1270
Number of pages7
JournalJapanese Journal of Thoracic Diseases
Volume34
Issue number11
Publication statusPublished - 1996
Externally publishedYes

Fingerprint

Mycobacterium chelonae
Clarithromycin
Lung Diseases
Sputum
Amikacin
Bacillus
Tuberculosis
Cefoxitin
Acids
Imipenem
Therapeutic Uses
Fever
Lung
DNA
Pharmaceutical Preparations

Keywords

  • Clarithromycin
  • DNA hybridization method
  • M. chelonae subsp. abscessus disease
  • MIC

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Naoki, K., Oosumi, M., Takasugi, T., Toyoda, T., Kawashiro, T., & Aoyagi, T. (1996). Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus. Japanese Journal of Thoracic Diseases, 34(11), 1264-1270.

Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus. / Naoki, K.; Oosumi, M.; Takasugi, T.; Toyoda, T.; Kawashiro, T.; Aoyagi, T.

In: Japanese Journal of Thoracic Diseases, Vol. 34, No. 11, 1996, p. 1264-1270.

Research output: Contribution to journalArticle

Naoki, K, Oosumi, M, Takasugi, T, Toyoda, T, Kawashiro, T & Aoyagi, T 1996, 'Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus', Japanese Journal of Thoracic Diseases, vol. 34, no. 11, pp. 1264-1270.
Naoki K, Oosumi M, Takasugi T, Toyoda T, Kawashiro T, Aoyagi T. Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus. Japanese Journal of Thoracic Diseases. 1996;34(11):1264-1270.
Naoki, K. ; Oosumi, M. ; Takasugi, T. ; Toyoda, T. ; Kawashiro, T. ; Aoyagi, T. / Two cases of pulmonary disease caused by Mycobacterium chelonae subsp. abscessus. In: Japanese Journal of Thoracic Diseases. 1996 ; Vol. 34, No. 11. pp. 1264-1270.
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