TY - JOUR
T1 - Two Japanese kindreds occurring endometrial cancer meeting new clinical criteria for hereditary non-polyposis colorectal cancer (HNPCC), Amsterdam Criteria II
AU - Banno, Kouji
AU - Susumu, Nobuyuki
AU - Hirao, Takeshi
AU - Yanokura, Megumi
AU - Hirasawa, Akira
AU - Aoki, Daisuke
AU - Udagawa, Yasuhiro
AU - Sugano, Kokichi
AU - Nozawa, Shiro
PY - 2004/8/1
Y1 - 2004/8/1
N2 - Hereditary non-polyposis colorectal cancer (HNPCC), also called Lynch syndrome, is an autosomal dominantly inherited disorder of cancer susceptibility. Patients with HNPCC exhibit an increased risk for HNPCC-associated extracolonic tumors such as cancer of the endometrium. HNPCC is associated with germline mutations in DNA mismatch repair (MMR) genes: hMLH1, hMSH2 and hMSH6. Here, we describe two Japanese kindreds (0.5%) who met the new clinical criteria for HNPCC, Amsterdam criteria II, from among 375 endometrial cancer patients treated at Keio University Hospital from 1990 to 2002. From these results, it was found that female HNPCC patients comprised approximately 0.5% of all endometrial cancer patients. Decreased expression of two MMR gene protein products (hMLH1 and HMSH6) was confirmed immunohistochemically in these two endometrial tumors in HNPCC kindreds. This case report provides important information on Japanese HNPCC patients occurring endometrial cancer.
AB - Hereditary non-polyposis colorectal cancer (HNPCC), also called Lynch syndrome, is an autosomal dominantly inherited disorder of cancer susceptibility. Patients with HNPCC exhibit an increased risk for HNPCC-associated extracolonic tumors such as cancer of the endometrium. HNPCC is associated with germline mutations in DNA mismatch repair (MMR) genes: hMLH1, hMSH2 and hMSH6. Here, we describe two Japanese kindreds (0.5%) who met the new clinical criteria for HNPCC, Amsterdam criteria II, from among 375 endometrial cancer patients treated at Keio University Hospital from 1990 to 2002. From these results, it was found that female HNPCC patients comprised approximately 0.5% of all endometrial cancer patients. Decreased expression of two MMR gene protein products (hMLH1 and HMSH6) was confirmed immunohistochemically in these two endometrial tumors in HNPCC kindreds. This case report provides important information on Japanese HNPCC patients occurring endometrial cancer.
KW - Endometrial cancer
KW - Hereditary non-polyposis colorectal cancer (HNPCC)
KW - hMLH1
KW - hMSH2
KW - hMSH6
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U2 - 10.1111/j.1447-0756.2004.00195.x
DO - 10.1111/j.1447-0756.2004.00195.x
M3 - Article
C2 - 15238104
AN - SCOPUS:4243102952
VL - 30
SP - 287
EP - 292
JO - Journal of Obstetrics and Gynaecology
JF - Journal of Obstetrics and Gynaecology
SN - 1341-8076
IS - 4
ER -