Two lung adenocarcinomas in the same lobe: Multiple primaries or intrapulmonary metastasis?

Kentaro Yoshimoto, Junji Yoshida, Genichiro Ishii, Mitsuyo Nishimura, Tomoyuki Hishida, Kanji Nagai

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Abnormal nodules were found in the left lung of a 52-year-old woman in segments 6 and 10 on a chest CT. These nodules showed no changes for 18 months, and we discontinued followup. Almost 5 years later, an abnormal shadow was found in her left lower lung field on a medical check-up chest X-ray. Chest CT revealed that the left segments 6 and 10 nodules had grown. We diagnosed these lesions as synchronous double primary lung cancers in the same lobe based on the disease history and performed a left lower lobectomy and lymph node dissection. Pathological examination of both tumors revealed adenocarcinoma of a mixed subtype with papillary and bronchioloalveolar carcinoma. Epidermal growth factor receptor gene mutations were examined, and the 2 lesions shared an L858R mutation. Although we expected EGFR gene mutation analysis would help us distinguish the 2 lesions from each other, it was of little help. Disease history can be more important in evaluating multiple pulmonary cancers.

Original languageEnglish
Pages (from-to)584-587
Number of pages4
JournalAnnals of Thoracic and Cardiovascular Surgery
Volume17
Issue number6
DOIs
Publication statusPublished - 2011
Externally publishedYes

Fingerprint

erbB-1 Genes
Thorax
Neoplasm Metastasis
Mutation
Lung Neoplasms
Bronchiolo-Alveolar Adenocarcinoma
Lung
Papillary Carcinoma
Lymph Node Excision
Adenocarcinoma
X-Rays
Adenocarcinoma of lung
Neoplasms

Keywords

  • Epidermal growth factor receptor
  • Gene mutation
  • Synchronous multiple primary lung cancers

ASJC Scopus subject areas

  • Surgery
  • Cardiology and Cardiovascular Medicine
  • Pulmonary and Respiratory Medicine
  • Gastroenterology

Cite this

Two lung adenocarcinomas in the same lobe : Multiple primaries or intrapulmonary metastasis? / Yoshimoto, Kentaro; Yoshida, Junji; Ishii, Genichiro; Nishimura, Mitsuyo; Hishida, Tomoyuki; Nagai, Kanji.

In: Annals of Thoracic and Cardiovascular Surgery, Vol. 17, No. 6, 2011, p. 584-587.

Research output: Contribution to journalArticle

Yoshimoto, Kentaro ; Yoshida, Junji ; Ishii, Genichiro ; Nishimura, Mitsuyo ; Hishida, Tomoyuki ; Nagai, Kanji. / Two lung adenocarcinomas in the same lobe : Multiple primaries or intrapulmonary metastasis?. In: Annals of Thoracic and Cardiovascular Surgery. 2011 ; Vol. 17, No. 6. pp. 584-587.
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