Two lung cancer patients with HIV infection who underwent adjuvant chemotherapy followed by surgery

Shigeki Suzuki, Hirotoshi Horio, Tai Hato, Masahiko Harada, Yusuke Okuma, Tunekazu Hishima

Research output: Contribution to journalArticle

Abstract

Background. With the advent of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV)-infected patients, causes of death from a wide variety of cancers have recently been increasing among this population in the United States and Europe. However, few reports have described patients with HIV who have been suffered from non-AIDS-defining cancer and undergone surgery for lung cancer in Japan. Cases. Case 1: A man in his 50s who was suffering from HIV infection from a month before his admission was given a diagnosis of lung cancer of the right upper lobe. His clinical stage was T2aN0M0. We performed video-assisted thoracoscopic surgery (VATS) lobectomy of right upper lobe and mediastinal lymph node dissection. Pathological diagnosis was adenocarcinoma (pT2aN2M0). The patient then received 4 cycles of adjuvant chemotherapy with cisplatin/vinorelbine. He has been well with no evidence of cancer recurrence for 10 months. Case 2: A man in his 70s was found to have lung cancer of the left upper lobe. His lung cancer clinical stage was T2bN0M0. He had a 20 year history of HIV infection, and underwent VATS lingular segmentectomy and mediastinal lymph node dissection because surgery was restricted by his low respiratory function. The pathological diagnosis was adenocarcinoma (pT3N2M0). Following surgery, the patient received 4 cycles of adjuvant chemotherapy with cisplatin/gemcitabine. However, intrapulmonary metastases appeared 10 months later. He has since been treated using docetaxel. Conclusion. We think that surgical treatment can be recommended for resectable lung cancer patients with HIV infection like non-HIV infectious cases. Adjuvant chemotherapy following surgery for non-small cell lung cancer was safe in these cases. However several points have not yet been established like drug interactions between antiretroviral agents and antitumor agents or adaptation for chemotherapy. The results of surgery in patients with HIV infection are satisfactory with these treatments as long as performance status, organ functions and immunological status remain good.

Original languageEnglish
Pages (from-to)284-289
Number of pages6
JournalJapanese Journal of Lung Cancer
Volume52
Issue number3
DOIs
Publication statusPublished - 2012 Jun

Fingerprint

Virus Diseases
Adjuvant Chemotherapy
Lung Neoplasms
HIV
Video-Assisted Thoracic Surgery
docetaxel
gemcitabine
Lymph Node Excision
Cisplatin
Adenocarcinoma
Anti-Retroviral Agents
Neoplasms
Segmental Mastectomy
Highly Active Antiretroviral Therapy
Drug Interactions
Non-Small Cell Lung Carcinoma
Antineoplastic Agents
Cause of Death
Japan
Neoplasm Metastasis

Keywords

  • Adjuvant chemotherapy
  • Highly active antiretroviral therapy (HAART)
  • Human immunodeficiency virus (HIV) infection
  • Non-AIDS-defining cancer
  • Primary lung cancer

ASJC Scopus subject areas

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Two lung cancer patients with HIV infection who underwent adjuvant chemotherapy followed by surgery. / Suzuki, Shigeki; Horio, Hirotoshi; Hato, Tai; Harada, Masahiko; Okuma, Yusuke; Hishima, Tunekazu.

In: Japanese Journal of Lung Cancer, Vol. 52, No. 3, 06.2012, p. 284-289.

Research output: Contribution to journalArticle

Suzuki, Shigeki ; Horio, Hirotoshi ; Hato, Tai ; Harada, Masahiko ; Okuma, Yusuke ; Hishima, Tunekazu. / Two lung cancer patients with HIV infection who underwent adjuvant chemotherapy followed by surgery. In: Japanese Journal of Lung Cancer. 2012 ; Vol. 52, No. 3. pp. 284-289.
@article{6432cc2f45904017bc42ee3beef2dec1,
title = "Two lung cancer patients with HIV infection who underwent adjuvant chemotherapy followed by surgery",
abstract = "Background. With the advent of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV)-infected patients, causes of death from a wide variety of cancers have recently been increasing among this population in the United States and Europe. However, few reports have described patients with HIV who have been suffered from non-AIDS-defining cancer and undergone surgery for lung cancer in Japan. Cases. Case 1: A man in his 50s who was suffering from HIV infection from a month before his admission was given a diagnosis of lung cancer of the right upper lobe. His clinical stage was T2aN0M0. We performed video-assisted thoracoscopic surgery (VATS) lobectomy of right upper lobe and mediastinal lymph node dissection. Pathological diagnosis was adenocarcinoma (pT2aN2M0). The patient then received 4 cycles of adjuvant chemotherapy with cisplatin/vinorelbine. He has been well with no evidence of cancer recurrence for 10 months. Case 2: A man in his 70s was found to have lung cancer of the left upper lobe. His lung cancer clinical stage was T2bN0M0. He had a 20 year history of HIV infection, and underwent VATS lingular segmentectomy and mediastinal lymph node dissection because surgery was restricted by his low respiratory function. The pathological diagnosis was adenocarcinoma (pT3N2M0). Following surgery, the patient received 4 cycles of adjuvant chemotherapy with cisplatin/gemcitabine. However, intrapulmonary metastases appeared 10 months later. He has since been treated using docetaxel. Conclusion. We think that surgical treatment can be recommended for resectable lung cancer patients with HIV infection like non-HIV infectious cases. Adjuvant chemotherapy following surgery for non-small cell lung cancer was safe in these cases. However several points have not yet been established like drug interactions between antiretroviral agents and antitumor agents or adaptation for chemotherapy. The results of surgery in patients with HIV infection are satisfactory with these treatments as long as performance status, organ functions and immunological status remain good.",
keywords = "Adjuvant chemotherapy, Highly active antiretroviral therapy (HAART), Human immunodeficiency virus (HIV) infection, Non-AIDS-defining cancer, Primary lung cancer",
author = "Shigeki Suzuki and Hirotoshi Horio and Tai Hato and Masahiko Harada and Yusuke Okuma and Tunekazu Hishima",
year = "2012",
month = "6",
doi = "10.2482/haigan.52.284",
language = "English",
volume = "52",
pages = "284--289",
journal = "Japanese Journal of Lung Cancer",
issn = "0386-9628",
publisher = "Japan Lung Cancer Society",
number = "3",

}

TY - JOUR

T1 - Two lung cancer patients with HIV infection who underwent adjuvant chemotherapy followed by surgery

AU - Suzuki, Shigeki

AU - Horio, Hirotoshi

AU - Hato, Tai

AU - Harada, Masahiko

AU - Okuma, Yusuke

AU - Hishima, Tunekazu

PY - 2012/6

Y1 - 2012/6

N2 - Background. With the advent of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV)-infected patients, causes of death from a wide variety of cancers have recently been increasing among this population in the United States and Europe. However, few reports have described patients with HIV who have been suffered from non-AIDS-defining cancer and undergone surgery for lung cancer in Japan. Cases. Case 1: A man in his 50s who was suffering from HIV infection from a month before his admission was given a diagnosis of lung cancer of the right upper lobe. His clinical stage was T2aN0M0. We performed video-assisted thoracoscopic surgery (VATS) lobectomy of right upper lobe and mediastinal lymph node dissection. Pathological diagnosis was adenocarcinoma (pT2aN2M0). The patient then received 4 cycles of adjuvant chemotherapy with cisplatin/vinorelbine. He has been well with no evidence of cancer recurrence for 10 months. Case 2: A man in his 70s was found to have lung cancer of the left upper lobe. His lung cancer clinical stage was T2bN0M0. He had a 20 year history of HIV infection, and underwent VATS lingular segmentectomy and mediastinal lymph node dissection because surgery was restricted by his low respiratory function. The pathological diagnosis was adenocarcinoma (pT3N2M0). Following surgery, the patient received 4 cycles of adjuvant chemotherapy with cisplatin/gemcitabine. However, intrapulmonary metastases appeared 10 months later. He has since been treated using docetaxel. Conclusion. We think that surgical treatment can be recommended for resectable lung cancer patients with HIV infection like non-HIV infectious cases. Adjuvant chemotherapy following surgery for non-small cell lung cancer was safe in these cases. However several points have not yet been established like drug interactions between antiretroviral agents and antitumor agents or adaptation for chemotherapy. The results of surgery in patients with HIV infection are satisfactory with these treatments as long as performance status, organ functions and immunological status remain good.

AB - Background. With the advent of highly active antiretroviral therapy (HAART) for human immunodeficiency virus (HIV)-infected patients, causes of death from a wide variety of cancers have recently been increasing among this population in the United States and Europe. However, few reports have described patients with HIV who have been suffered from non-AIDS-defining cancer and undergone surgery for lung cancer in Japan. Cases. Case 1: A man in his 50s who was suffering from HIV infection from a month before his admission was given a diagnosis of lung cancer of the right upper lobe. His clinical stage was T2aN0M0. We performed video-assisted thoracoscopic surgery (VATS) lobectomy of right upper lobe and mediastinal lymph node dissection. Pathological diagnosis was adenocarcinoma (pT2aN2M0). The patient then received 4 cycles of adjuvant chemotherapy with cisplatin/vinorelbine. He has been well with no evidence of cancer recurrence for 10 months. Case 2: A man in his 70s was found to have lung cancer of the left upper lobe. His lung cancer clinical stage was T2bN0M0. He had a 20 year history of HIV infection, and underwent VATS lingular segmentectomy and mediastinal lymph node dissection because surgery was restricted by his low respiratory function. The pathological diagnosis was adenocarcinoma (pT3N2M0). Following surgery, the patient received 4 cycles of adjuvant chemotherapy with cisplatin/gemcitabine. However, intrapulmonary metastases appeared 10 months later. He has since been treated using docetaxel. Conclusion. We think that surgical treatment can be recommended for resectable lung cancer patients with HIV infection like non-HIV infectious cases. Adjuvant chemotherapy following surgery for non-small cell lung cancer was safe in these cases. However several points have not yet been established like drug interactions between antiretroviral agents and antitumor agents or adaptation for chemotherapy. The results of surgery in patients with HIV infection are satisfactory with these treatments as long as performance status, organ functions and immunological status remain good.

KW - Adjuvant chemotherapy

KW - Highly active antiretroviral therapy (HAART)

KW - Human immunodeficiency virus (HIV) infection

KW - Non-AIDS-defining cancer

KW - Primary lung cancer

UR - http://www.scopus.com/inward/record.url?scp=84865284521&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84865284521&partnerID=8YFLogxK

U2 - 10.2482/haigan.52.284

DO - 10.2482/haigan.52.284

M3 - Article

AN - SCOPUS:84865284521

VL - 52

SP - 284

EP - 289

JO - Japanese Journal of Lung Cancer

JF - Japanese Journal of Lung Cancer

SN - 0386-9628

IS - 3

ER -