Two major subgroups of human T-Cell leukemia virus-1 in Japan

Haruhiko Siomi, Tetsuya Nosaka, Takahiko Saida, Hiroshi Miwa, Yorio Hinuma, Shigeru Shirakawa, Naoaki Miyamoto, Toshifumi Kondo, Koichi Araki, Michito Ichimaru, Akira B. Miura, Masakazu Hatanaka

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

Original languageEnglish
Pages (from-to)377-383
Number of pages7
JournalVirus Genes
Volume1
Issue number4
DOIs
Publication statusPublished - 1988 Jul
Externally publishedYes

Fingerprint

Deltaretrovirus
Spinal Cord Diseases
Adult T Cell Leukemia Lymphoma
Human T-lymphotropic virus 1
Japan
Proviruses
Lymph Nodes
Genome
Lymphocytes
T-Lymphocytes
Cell Line
DNA

Keywords

  • ATL
  • HAM
  • HTLV-1
  • leukemia
  • myelopathy
  • variants

ASJC Scopus subject areas

  • Virology
  • Immunology
  • Applied Microbiology and Biotechnology
  • Molecular Biology
  • Genetics

Cite this

Siomi, H., Nosaka, T., Saida, T., Miwa, H., Hinuma, Y., Shirakawa, S., ... Hatanaka, M. (1988). Two major subgroups of human T-Cell leukemia virus-1 in Japan. Virus Genes, 1(4), 377-383. https://doi.org/10.1007/BF00257100

Two major subgroups of human T-Cell leukemia virus-1 in Japan. / Siomi, Haruhiko; Nosaka, Tetsuya; Saida, Takahiko; Miwa, Hiroshi; Hinuma, Yorio; Shirakawa, Shigeru; Miyamoto, Naoaki; Kondo, Toshifumi; Araki, Koichi; Ichimaru, Michito; Miura, Akira B.; Hatanaka, Masakazu.

In: Virus Genes, Vol. 1, No. 4, 07.1988, p. 377-383.

Research output: Contribution to journalArticle

Siomi, H, Nosaka, T, Saida, T, Miwa, H, Hinuma, Y, Shirakawa, S, Miyamoto, N, Kondo, T, Araki, K, Ichimaru, M, Miura, AB & Hatanaka, M 1988, 'Two major subgroups of human T-Cell leukemia virus-1 in Japan', Virus Genes, vol. 1, no. 4, pp. 377-383. https://doi.org/10.1007/BF00257100
Siomi H, Nosaka T, Saida T, Miwa H, Hinuma Y, Shirakawa S et al. Two major subgroups of human T-Cell leukemia virus-1 in Japan. Virus Genes. 1988 Jul;1(4):377-383. https://doi.org/10.1007/BF00257100
Siomi, Haruhiko ; Nosaka, Tetsuya ; Saida, Takahiko ; Miwa, Hiroshi ; Hinuma, Yorio ; Shirakawa, Shigeru ; Miyamoto, Naoaki ; Kondo, Toshifumi ; Araki, Koichi ; Ichimaru, Michito ; Miura, Akira B. ; Hatanaka, Masakazu. / Two major subgroups of human T-Cell leukemia virus-1 in Japan. In: Virus Genes. 1988 ; Vol. 1, No. 4. pp. 377-383.
@article{e80326dc716c447f9dbdb9852da3e99c,
title = "Two major subgroups of human T-Cell leukemia virus-1 in Japan",
abstract = "T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.",
keywords = "ATL, HAM, HTLV-1, leukemia, myelopathy, variants",
author = "Haruhiko Siomi and Tetsuya Nosaka and Takahiko Saida and Hiroshi Miwa and Yorio Hinuma and Shigeru Shirakawa and Naoaki Miyamoto and Toshifumi Kondo and Koichi Araki and Michito Ichimaru and Miura, {Akira B.} and Masakazu Hatanaka",
year = "1988",
month = "7",
doi = "10.1007/BF00257100",
language = "English",
volume = "1",
pages = "377--383",
journal = "Virus Genes",
issn = "0920-8569",
publisher = "Springer Netherlands",
number = "4",

}

TY - JOUR

T1 - Two major subgroups of human T-Cell leukemia virus-1 in Japan

AU - Siomi, Haruhiko

AU - Nosaka, Tetsuya

AU - Saida, Takahiko

AU - Miwa, Hiroshi

AU - Hinuma, Yorio

AU - Shirakawa, Shigeru

AU - Miyamoto, Naoaki

AU - Kondo, Toshifumi

AU - Araki, Koichi

AU - Ichimaru, Michito

AU - Miura, Akira B.

AU - Hatanaka, Masakazu

PY - 1988/7

Y1 - 1988/7

N2 - T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

AB - T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

KW - ATL

KW - HAM

KW - HTLV-1

KW - leukemia

KW - myelopathy

KW - variants

UR - http://www.scopus.com/inward/record.url?scp=18344408604&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344408604&partnerID=8YFLogxK

U2 - 10.1007/BF00257100

DO - 10.1007/BF00257100

M3 - Article

C2 - 3265821

AN - SCOPUS:18344408604

VL - 1

SP - 377

EP - 383

JO - Virus Genes

JF - Virus Genes

SN - 0920-8569

IS - 4

ER -