Two major subgroups of human T-Cell leukemia virus-1 in Japan

Haruhiko Siomi; Tetsuya Nosaka; Takahiko Saida; Hiroshi Miwa; Yorio Hinuma; Shigeru Shirakawa; Naoaki Miyamoto; Toshifumi Kondo; Koichi Araki; Michito Ichimaru; Akira B. Miura; Masakazu Hatanaka

doi:10.1007/BF00257100

Two major subgroups of human T-Cell leukemia virus-1 in Japan

Haruhiko Siomi, Tetsuya Nosaka, Takahiko Saida, Hiroshi Miwa, Yorio Hinuma, Shigeru Shirakawa, Naoaki Miyamoto, Toshifumi Kondo, Koichi Araki, Michito Ichimaru, Akira B. Miura, Masakazu Hatanaka

Research output: Contribution to journal › Article › peer-review

7 Citations (Scopus)

Abstract

T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

Original language	English
Pages (from-to)	377-383
Number of pages	7
Journal	Virus Genes
Volume	1
Issue number	4
DOIs	https://doi.org/10.1007/BF00257100
Publication status	Published - 1988 Jul 1
Externally published	Yes

Keywords

ATL
HAM
HTLV-1
leukemia
myelopathy
variants

ASJC Scopus subject areas

Molecular Biology
Genetics
Virology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF00257100

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title = "Two major subgroups of human T-Cell leukemia virus-1 in Japan",

abstract = "T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.",

keywords = "ATL, HAM, HTLV-1, leukemia, myelopathy, variants",

author = "Haruhiko Siomi and Tetsuya Nosaka and Takahiko Saida and Hiroshi Miwa and Yorio Hinuma and Shigeru Shirakawa and Naoaki Miyamoto and Toshifumi Kondo and Koichi Araki and Michito Ichimaru and Miura, {Akira B.} and Masakazu Hatanaka",

year = "1988",

month = jul,

day = "1",

doi = "10.1007/BF00257100",

language = "English",

volume = "1",

pages = "377--383",

journal = "Virus Genes",

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publisher = "Springer Netherlands",

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}

TY - JOUR

T1 - Two major subgroups of human T-Cell leukemia virus-1 in Japan

AU - Siomi, Haruhiko

AU - Nosaka, Tetsuya

AU - Saida, Takahiko

AU - Miwa, Hiroshi

AU - Hinuma, Yorio

AU - Shirakawa, Shigeru

AU - Miyamoto, Naoaki

AU - Kondo, Toshifumi

AU - Araki, Koichi

AU - Ichimaru, Michito

AU - Miura, Akira B.

AU - Hatanaka, Masakazu

PY - 1988/7/1

Y1 - 1988/7/1

N2 - T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

AB - T lymphocytes of patients with human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy (HAM) were cultured. After cultivating for several months, HAM-derived cell lines were tested for the presence of HTLV-1 proviral genome. We have found two major subgroups, the SacI type and the PstI type,of HTLV-1 by the restriction map analysis. They were almost equally distributed among HAM patients. We have also found two types of the provirus in DNA derived from fresh peripheral blood lymphocytes (PBL) or lymph node cells of adult T-cell leukemia/lymphoma (ATL) patients. The PstI type proviruses were predominant in ATL patients. It was concluded that two major subgroups of HTLV-1 exist in Japan and both types have an ability to cause either of two diseases, ATL or HAM.

KW - ATL

KW - HAM

KW - HTLV-1

KW - leukemia

KW - myelopathy

KW - variants

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U2 - 10.1007/BF00257100

DO - 10.1007/BF00257100

M3 - Article

C2 - 3265821

AN - SCOPUS:18344408604

SN - 0920-8569

VL - 1

SP - 377

EP - 383

JO - Virus Genes

JF - Virus Genes

IS - 4

ER -

Two major subgroups of human T-Cell leukemia virus-1 in Japan

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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