Abstract
Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
| Original language | English |
|---|---|
| Pages (from-to) | 130-134 |
| Number of pages | 5 |
| Journal | Journal of Natural Medicines |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2015 Jan |
Keywords
- Diterpenoids
- Estrogen sulfotransferase
- Inhibitor
- Labiatae
- Leonotis leonurus
ASJC Scopus subject areas
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry
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Cite this
Narukawa, Y., Komori, M., Niimura, A., Noguchi, H., & Kiuchi, F. (2015). Two new diterpenoids from Leonotis leonurus R. Br. Journal of Natural Medicines, 69(1), 130-134. https://doi.org/10.1007/s11418-014-0868-2