Two new diterpenoids from Leonotis leonurus R. Br.

Yuji Narukawa, Miyuki Komori, Akiko Niimura, Hitomi Noguchi, Fumiyuki Kiuchi

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

Original languageEnglish
Pages (from-to)130-134
Number of pages5
JournalJournal of Natural Medicines
Volume69
Issue number1
DOIs
Publication statusPublished - 2015 Jan

Keywords

  • Diterpenoids
  • Estrogen sulfotransferase
  • Inhibitor
  • Labiatae
  • Leonotis leonurus

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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