Two new diterpenoids from Leonotis leonurus R. Br.

Yuji Narukawa; Miyuki Komori; Akiko Niimura; Hitomi Noguchi; Fumiyuki Kiuchi

doi:10.1007/s11418-014-0868-2

Two new diterpenoids from Leonotis leonurus R. Br.

Yuji Narukawa, Miyuki Komori, Akiko Niimura, Hitomi Noguchi, Fumiyuki Kiuchi

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

4 Citations (Scopus)

Abstract

Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

Original language	English
Pages (from-to)	130-134
Number of pages	5
Journal	Journal of Natural Medicines
Volume	69
Issue number	1
DOIs	https://doi.org/10.1007/s11418-014-0868-2
Publication status	Published - 2015 Jan

Keywords

Diterpenoids
Estrogen sulfotransferase
Inhibitor
Labiatae
Leonotis leonurus

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1007/s11418-014-0868-2

Fingerprint Dive into the research topics of 'Two new diterpenoids from Leonotis leonurus R. Br.'. Together they form a unique fingerprint.

Cite this

@article{87e0bdba064c400ba6ea89a2731c94ac,

title = "Two new diterpenoids from Leonotis leonurus R. Br.",

abstract = "Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.",

keywords = "Diterpenoids, Estrogen sulfotransferase, Inhibitor, Labiatae, Leonotis leonurus",

author = "Yuji Narukawa and Miyuki Komori and Akiko Niimura and Hitomi Noguchi and Fumiyuki Kiuchi",

year = "2015",

month = jan,

doi = "10.1007/s11418-014-0868-2",

language = "English",

volume = "69",

pages = "130--134",

journal = "Journal of Natural Medicines",

issn = "1861-0293",

publisher = "Springer Japan",

number = "1",

}

TY - JOUR

T1 - Two new diterpenoids from Leonotis leonurus R. Br.

AU - Narukawa, Yuji

AU - Komori, Miyuki

AU - Niimura, Akiko

AU - Noguchi, Hitomi

AU - Kiuchi, Fumiyuki

PY - 2015/1

Y1 - 2015/1

N2 - Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

AB - Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

KW - Diterpenoids

KW - Estrogen sulfotransferase

KW - Inhibitor

KW - Labiatae

KW - Leonotis leonurus

UR - http://www.scopus.com/inward/record.url?scp=84915757257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84915757257&partnerID=8YFLogxK

U2 - 10.1007/s11418-014-0868-2

DO - 10.1007/s11418-014-0868-2

M3 - Review article

C2 - 25223430

AN - SCOPUS:84915757257

VL - 69

SP - 130

EP - 134

JO - Journal of Natural Medicines

JF - Journal of Natural Medicines

SN - 1861-0293

IS - 1

ER -