Abstract
Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
| Original language | English |
|---|---|
| Pages (from-to) | 130-134 |
| Number of pages | 5 |
| Journal | Journal of Natural Medicines |
| Volume | 69 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Diterpenoids
- Estrogen sulfotransferase
- Inhibitor
- Labiatae
- Leonotis leonurus
ASJC Scopus subject areas
- Complementary and alternative medicine
- Organic Chemistry
- Drug Discovery
- Pharmaceutical Science
Cite this
Two new diterpenoids from Leonotis leonurus R. Br. / Narukawa, Yuuji; Komori, Miyuki; Niimura, Akiko; Noguchi, Hitomi; Kiuchi, Fumiyuki.
In: Journal of Natural Medicines, Vol. 69, No. 1, 2014, p. 130-134.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Two new diterpenoids from Leonotis leonurus R. Br.
AU - Narukawa, Yuuji
AU - Komori, Miyuki
AU - Niimura, Akiko
AU - Noguchi, Hitomi
AU - Kiuchi, Fumiyuki
PY - 2014
Y1 - 2014
N2 - Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
AB - Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.
KW - Diterpenoids
KW - Estrogen sulfotransferase
KW - Inhibitor
KW - Labiatae
KW - Leonotis leonurus
UR - http://www.scopus.com/inward/record.url?scp=84915757257&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84915757257&partnerID=8YFLogxK
U2 - 10.1007/s11418-014-0868-2
DO - 10.1007/s11418-014-0868-2
M3 - Article
VL - 69
SP - 130
EP - 134
JO - Journal of Natural Medicines
JF - Journal of Natural Medicines
SN - 1861-0293
IS - 1
ER -