Two new diterpenoids from Leonotis leonurus R. Br.

Yuji Narukawa; Miyuki Komori; Akiko Niimura; Hitomi Noguchi; Fumiyuki Kiuchi

doi:10.1007/s11418-014-0868-2

Two new diterpenoids from Leonotis leonurus R. Br.

Yuji Narukawa, Miyuki Komori, Akiko Niimura, Hitomi Noguchi, Fumiyuki Kiuchi

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

6 Citations (Scopus)

Abstract

Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

Original language	English
Pages (from-to)	130-134
Number of pages	5
Journal	Journal of Natural Medicines
Volume	69
Issue number	1
DOIs	https://doi.org/10.1007/s11418-014-0868-2
Publication status	Published - 2015 Jan

Keywords

Diterpenoids
Estrogen sulfotransferase
Inhibitor
Labiatae
Leonotis leonurus

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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10.1007/s11418-014-0868-2

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abstract = "Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.",

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author = "Yuji Narukawa and Miyuki Komori and Akiko Niimura and Hitomi Noguchi and Fumiyuki Kiuchi",

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T1 - Two new diterpenoids from Leonotis leonurus R. Br.

AU - Narukawa, Yuji

AU - Komori, Miyuki

AU - Niimura, Akiko

AU - Noguchi, Hitomi

AU - Kiuchi, Fumiyuki

PY - 2015/1

Y1 - 2015/1

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AB - Two new diterpenoids, 14α-hydroxy-9α,13α-epoxylabd-5(6)-en-7-on-16,15-olide (1) and 13ξ-hydroxylabd-5(6),8(9)-dien-7-on-16,15-olide (2) along with six known diterpenoids were isolated from the aerial parts of Leonotis leonurus R. Br. These structures were determined on the basis of spectroscopic analyses. Some of the isolated compounds showed weak to moderate estrogen sulfotransferase inhibitory activity.

KW - Diterpenoids

KW - Estrogen sulfotransferase

KW - Inhibitor

KW - Labiatae

KW - Leonotis leonurus

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Two new diterpenoids from Leonotis leonurus R. Br.

Abstract

Keywords

ASJC Scopus subject areas

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