Two new monoterpene glycosides and trypanocidal terpenoids from Dracocephalum kotschyi

Soodabeh Saeidnia, Ahmad Reza Gohari, Nahoko Uchiyama, Michiho Ito, Gisho Honda, Fumiyuki Kiuchi

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

From the whole plant of Dracocephalum kotschyi BOISS., two new monoterpene glycosides (9, 10), together with seven known terpenoids and a phytosterol (1-8), were isolated. Their structures were determined to be limonen-10-al (1), geranial (2), neral (3), β-sitosterol (4), oleanolic acid (5), ursolic acid (6), p-mentha-8-en-1,2-diol (7), colosolic acid (8), limonen-10-ol 10-O-β-D-glucopyranoside (9), and limonen-10-ol 10-O-β-D- glucopyranosyl-(1→2)-β-D-glucopyranoside (10). Compounds 1 (3.1 μM), 2 (3.1 μM), 3 (3.1 μM), 5 (6.2 μM), 6 (6.2 μM), and 8 (6.2 μM) were effective against epimastigotes of Trypanosoma cruzi.

Original languageEnglish
Pages (from-to)1249-1250
Number of pages2
JournalChemical and Pharmaceutical Bulletin
Volume52
Issue number10
DOIs
Publication statusPublished - 2004 Oct 1
Externally publishedYes

Keywords

  • Dracocephalum kotschyi
  • Monoterpene glucoside
  • Trypanocidal activity

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery

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