Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

Kenya Honda; Akinori Takaoka; Tadatsugu Taniguchi

doi:10.1016/j.immuni.2006.08.009

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

Kenya Honda, Akinori Takaoka, Tadatsugu Taniguchi

Research output: Contribution to journal › Review article › peer-review

971 Citations (Scopus)

Abstract

Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

Original language	English
Pages (from-to)	349-360
Number of pages	12
Journal	Immunity
Volume	25
Issue number	3
DOIs	https://doi.org/10.1016/j.immuni.2006.08.009
Publication status	Published - 2006 Sept
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.immuni.2006.08.009

Cite this

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title = "Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors",

abstract = "Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.",

author = "Kenya Honda and Akinori Takaoka and Tadatsugu Taniguchi",

note = "Funding Information: We thank J. Vilcek, E. Barsoumian, Y. Ohba, H. Negishi, and H. Yanai for valuable discussion and advice. This work was supported by Kakenhi (Grant-in-Aid for Scientific Research) on Priority Areas “Integrative Research Toward the Conquest of Cancer” from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Uehara Memorial Foundation.",

year = "2006",

month = sep,

doi = "10.1016/j.immuni.2006.08.009",

language = "English",

volume = "25",

pages = "349--360",

journal = "Immunity",

issn = "1074-7613",

publisher = "Cell Press",

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T1 - Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

AU - Honda, Kenya

AU - Takaoka, Akinori

AU - Taniguchi, Tadatsugu

N1 - Funding Information: We thank J. Vilcek, E. Barsoumian, Y. Ohba, H. Negishi, and H. Yanai for valuable discussion and advice. This work was supported by Kakenhi (Grant-in-Aid for Scientific Research) on Priority Areas “Integrative Research Toward the Conquest of Cancer” from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and the Uehara Memorial Foundation.

PY - 2006/9

Y1 - 2006/9

N2 - Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

AB - Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

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DO - 10.1016/j.immuni.2006.08.009

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SN - 1074-7613

VL - 25

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JO - Immunity

JF - Immunity

IS - 3

ER -

Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

Abstract

ASJC Scopus subject areas

UN SDGs

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