Type I Inteferon Gene Induction by the Interferon Regulatory Factor Family of Transcription Factors

Kenya Honda, Akinori Takaoka, Tadatsugu Taniguchi

Research output: Contribution to journalReview article

712 Citations (Scopus)

Abstract

Induction of type I interferons (IFNs) by viruses and other pathogens is crucial for innate immunity, and it is mediated by the activation of pattern-recognition receptors, such as Toll-like receptors and cytosolic receptors such as RIG-I and MDA5. The type I IFN induction is primarily controlled at the gene transcriptional level, wherein a family of transcription factors, interferon regulatory factors (IRFs), plays central roles. Here, we summarize the recent studies on IRFs, providing a paradigm of how genes are ingeniously regulated during immune responses. We also consider some evolutional aspects on the IFN-IRF system.

Original languageEnglish
Pages (from-to)349-360
Number of pages12
JournalImmunity
Volume25
Issue number3
DOIs
Publication statusPublished - 2006 Sep
Externally publishedYes

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ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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