Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis

Tsutomu Takeuchi, Tohru Abe

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Two of the key events in the pathogenesis of rheumatoid arthritis are the synovial cell proliferation and lymphocyte infiltration into the synovium. The resulting synovitis is longlasting and leads to destructive arthritis, which is a hallmark of rheumatoid arthritis. Accumulating evidence suggests that one of the key biochemical events in the altered cell function of RA is phosphorylation of the tyrosine residues of proteins. In this paper we review the cellular components participating in the chronic inflammation of RA joints. We present the results of analyzing tyrosine phosphorylated proteins of synovial cells from RA patients and discuss a possible pathogenic role of non-receptor tyrosine kinase in RA.

Original languageEnglish
Pages (from-to)365-381
Number of pages17
JournalInternational Reviews of Immunology
Volume17
Issue number5-6
Publication statusPublished - 1998
Externally publishedYes

Fingerprint

Tyrosine
Rheumatoid Arthritis
Synovitis
Synovial Membrane
Protein-Tyrosine Kinases
Arthritis
Proteins
Joints
Phosphorylation
Cell Proliferation
Lymphocytes
Inflammation

Keywords

  • Adhesion molecules
  • FAK
  • Integrins
  • Signal transduction
  • Tyrosine kinase

ASJC Scopus subject areas

  • Immunology

Cite this

Tyrosine phosphorylated proteins in synovial cells of rheumatoid arthritis. / Takeuchi, Tsutomu; Abe, Tohru.

In: International Reviews of Immunology, Vol. 17, No. 5-6, 1998, p. 365-381.

Research output: Contribution to journalArticle

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