U-shaped association between abnormal serum uric acid levels and COVID-19 severity: reports from the Japan COVID-19 Task Force

The Japan COVID-19 Task Force

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: This study aimed to identify the relationship between abnormal serum uric acid levels or a history of hyperuricemia and COVID-19 severity in the Japanese population. Methods: We included 1523 patients enrolled in the Japan COVID-19 Task Force cohort between February 2020 and May 2021. We compared the clinical characteristics, including co-morbidities, laboratory findings, and outcomes, particularly invasive mechanical ventilation (IMV), among patients with and without abnormal uric acid levels or a history of hyperuricemia. Results: Patients with high serum uric acid levels were older and had higher body weight and body mass index than those without. In addition, the multiple logistic regression analysis revealed a significant association between high serum uric acid levels or a history of hyperuricemia and an increased risk of IMV (odds ratio [OR] = 1.77; P = 0.03/OR = 1.56; P = 0.04). Moreover, patients with low uric acid levels on admission were also associated significantly with the requirement of IMV (OR = 5.09; P <0.0001). Conclusion: Abnormal serum uric acid levels or a history of hyperuricemia were significantly associated with COVID-19 severity in the Japanese cohort.

Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalInternational Journal of Infectious Diseases
Volume122
DOIs
Publication statusPublished - 2022 Sep

Keywords

  • COVID-19
  • High serum uric acid
  • Hyperuricemia
  • Hypouricemia
  • Low serum uric acid
  • Respiratory care
  • Severity

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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