This research proposes the multispectral image retrieval method by using spectral feature and semantic computing which is not many studies have focused. The main contributions are to enhance the effectiveness and advantageous of global environmental analysis system and realize semantic associative search and analysis. In this work, we study multispectral image retrieval using spectral feature computed in multispectral semantic-image space. The multispectral semantic-image space is supposing to realize the interpretation of substance (materials) on earth surface which can be provided the analyzed results as human-level interpretation. Our essential approach is utilizing the semantic computing to measure the similarity between multispectral image and the meaningful keywords which according to the user's contexts. Our research results found that this method possible to acquire the spectral feature from the multispectral image and could be used in multispectral image retrieval. In this study, a multispectral image is used as the image query according to user's query contexts. Moreover, the method performance of UAV-based multispectral aerial image retrieval using spectral feature and semantic computing is measured based on the queries with three contexts of multispectral image which is indicated by previous study on agricultural monitoring system and semantic interpretation model.