Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi, Daisuke Asano, Masashi Sawamura, Yasuko In, Toshimasa Ishida, Masaya Imoto

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

Original languageEnglish
Pages (from-to)1658-1661
Number of pages4
JournalOrganic Letters
Volume18
Issue number7
DOIs
Publication statusPublished - 2016 Apr 15

Fingerprint

Brevibacillus
Bearings (structural)
Porifera
Sulfur
Isomers
Cell Movement
Tumors
Nitrogen
sulfur
tumors
isomers
Cells
Nuclear magnetic resonance
X-Rays
Derivatives
nitrogen
X rays
nuclear magnetic resonance
rings
configurations

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp. / Igarashi, Yasuhiro; Asano, Daisuke; Sawamura, Masashi; In, Yasuko; Ishida, Toshimasa; Imoto, Masaya.

In: Organic Letters, Vol. 18, No. 7, 15.04.2016, p. 1658-1661.

Research output: Contribution to journalArticle

Igarashi, Yasuhiro ; Asano, Daisuke ; Sawamura, Masashi ; In, Yasuko ; Ishida, Toshimasa ; Imoto, Masaya. / Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp. In: Organic Letters. 2016 ; Vol. 18, No. 7. pp. 1658-1661.
@article{a6709e706d474d1382908374117c42a0,
title = "Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.",
abstract = "Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.",
author = "Yasuhiro Igarashi and Daisuke Asano and Masashi Sawamura and Yasuko In and Toshimasa Ishida and Masaya Imoto",
year = "2016",
month = "4",
day = "15",
doi = "10.1021/acs.orglett.6b00531",
language = "English",
volume = "18",
pages = "1658--1661",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "7",

}

TY - JOUR

T1 - Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

AU - Igarashi, Yasuhiro

AU - Asano, Daisuke

AU - Sawamura, Masashi

AU - In, Yasuko

AU - Ishida, Toshimasa

AU - Imoto, Masaya

PY - 2016/4/15

Y1 - 2016/4/15

N2 - Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

AB - Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

UR - http://www.scopus.com/inward/record.url?scp=84963808617&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84963808617&partnerID=8YFLogxK

U2 - 10.1021/acs.orglett.6b00531

DO - 10.1021/acs.orglett.6b00531

M3 - Article

C2 - 26998643

AN - SCOPUS:84963808617

VL - 18

SP - 1658

EP - 1661

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 7

ER -