Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi; Daisuke Asano; Masashi Sawamura; Yasuko In; Toshimasa Ishida; Masaya Imoto

doi:10.1021/acs.orglett.6b00531

Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi, Daisuke Asano, Masashi Sawamura, Yasuko In, Toshimasa Ishida, Masaya Imoto

Department of Biosciences and Informatics

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

Abstract

Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

Original language	English
Pages (from-to)	1658-1661
Number of pages	4
Journal	Organic Letters
Volume	18
Issue number	7
DOIs	https://doi.org/10.1021/acs.orglett.6b00531
Publication status	Published - 2016 Apr 15

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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abstract = "Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.",

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AU - Igarashi, Yasuhiro

AU - Asano, Daisuke

AU - Sawamura, Masashi

AU - In, Yasuko

AU - Ishida, Toshimasa

AU - Imoto, Masaya

PY - 2016/4/15

Y1 - 2016/4/15

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AB - Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

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Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

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