Ulbactins F and G, Polycyclic Thiazoline Derivatives with Tumor Cell Migration Inhibitory Activity from Brevibacillus sp.

Yasuhiro Igarashi, Daisuke Asano, Masashi Sawamura, Yasuko In, Toshimasa Ishida, Masaya Imoto

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Two new structurally unique compounds bearing a nitrogen- and sulfur-containing tricyclic ring system, ulbactin F (1) and its diastereomeric isomer ulbactin G (2), were isolated from the culture extract of a sponge-derived Brevibacillus sp. The structures and absolute configurations of 1 and 2 were determined by NMR analysis and X-ray crystallographic analysis. These compounds inhibit the migration of tumor cells in the submicromolar to micromolar range.

Original languageEnglish
Pages (from-to)1658-1661
Number of pages4
JournalOrganic Letters
Volume18
Issue number7
DOIs
Publication statusPublished - 2016 Apr 15

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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