Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

Keiichiro Saigusa, Katsuyoshi Matsuoka, Shinya Sugimoto, Mari Arai, Hiroki Kiyohara, Kozue Takeshita, Shinta Mizuno, Kiyoto Mori, Kosaku Nanki, Tatsuya Takeshita, Yoshihiro Nakazato, Tomoharu Yajima, Makoto Naganuma, Tadakazu Hisamatsu, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aim: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is characterized by periods of remission and episodes of relapse. Mucosal healing is an emerging therapeutic target in UC and various scoring systems have been used. The UC endoscopic index of severity (UCEIS) is the only validated endoscopic index at present, with minimum interobserver variation. Correlation of UCEIS scores after treatment and clinical outcomes of UC has not been examined. In the present study, we aimed to evaluate the usefulness of UCEIS after treatment with infliximab. Methods: The medical records of 82 UC patients, treated with infliximab at Keio University Hospital between October 2010 and July 2013, were reviewed retrospectively. Endoscopic findings were evaluated based on the UCEIS. Results: Mean pre-therapeutic UCEIS score was 5.1. Pre-therapeutic UCEIS scores were not associated with short-term outcomes. Forty-five patients underwent colonoscopy at 3–12 months after starting treatment; mean post-therapeutic UCEIS score was 2.4, with a score of 0–1 in 16 (35.6%) patients, 2–4 in 19 (42.2%) patients, and 5–8 in 10 (22.2%) patients. Importantly, a post-therapeutic UCEIS score of 0 or 1 after treatment was associated with a favorable long-term outcome. Conclusion: UCEIS score is a useful instrument for evaluating endoscopic improvement in UC patients treated with infliximab, and mucosal healing may be defined with a UCEIS score of 0 or 1.

Original languageEnglish
Pages (from-to)665-670
Number of pages6
JournalDigestive Endoscopy
Volume28
Issue number6
DOIs
Publication statusPublished - 2016 Sep 1

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Ulcerative Colitis
Therapeutics
Observer Variation
Infliximab
Colonoscopy
Inflammatory Bowel Diseases
Medical Records
Recurrence

Keywords

  • infliximab
  • mayo endoscopic score
  • mucosal healing
  • ulcerative colitis
  • ulcerative colitis endoscopic index of severity (UCEIS)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Gastroenterology

Cite this

Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab. / Saigusa, Keiichiro; Matsuoka, Katsuyoshi; Sugimoto, Shinya; Arai, Mari; Kiyohara, Hiroki; Takeshita, Kozue; Mizuno, Shinta; Mori, Kiyoto; Nanki, Kosaku; Takeshita, Tatsuya; Nakazato, Yoshihiro; Yajima, Tomoharu; Naganuma, Makoto; Hisamatsu, Tadakazu; Ogata, Haruhiko; Iwao, Yasushi; Kanai, Takanori.

In: Digestive Endoscopy, Vol. 28, No. 6, 01.09.2016, p. 665-670.

Research output: Contribution to journalArticle

Saigusa, K, Matsuoka, K, Sugimoto, S, Arai, M, Kiyohara, H, Takeshita, K, Mizuno, S, Mori, K, Nanki, K, Takeshita, T, Nakazato, Y, Yajima, T, Naganuma, M, Hisamatsu, T, Ogata, H, Iwao, Y & Kanai, T 2016, 'Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab', Digestive Endoscopy, vol. 28, no. 6, pp. 665-670. https://doi.org/10.1111/den.12655
Saigusa, Keiichiro ; Matsuoka, Katsuyoshi ; Sugimoto, Shinya ; Arai, Mari ; Kiyohara, Hiroki ; Takeshita, Kozue ; Mizuno, Shinta ; Mori, Kiyoto ; Nanki, Kosaku ; Takeshita, Tatsuya ; Nakazato, Yoshihiro ; Yajima, Tomoharu ; Naganuma, Makoto ; Hisamatsu, Tadakazu ; Ogata, Haruhiko ; Iwao, Yasushi ; Kanai, Takanori. / Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab. In: Digestive Endoscopy. 2016 ; Vol. 28, No. 6. pp. 665-670.
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T1 - Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab

AU - Saigusa, Keiichiro

AU - Matsuoka, Katsuyoshi

AU - Sugimoto, Shinya

AU - Arai, Mari

AU - Kiyohara, Hiroki

AU - Takeshita, Kozue

AU - Mizuno, Shinta

AU - Mori, Kiyoto

AU - Nanki, Kosaku

AU - Takeshita, Tatsuya

AU - Nakazato, Yoshihiro

AU - Yajima, Tomoharu

AU - Naganuma, Makoto

AU - Hisamatsu, Tadakazu

AU - Ogata, Haruhiko

AU - Iwao, Yasushi

AU - Kanai, Takanori

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N2 - Background and Aim: Ulcerative colitis (UC) is a chronic inflammatory bowel disease that is characterized by periods of remission and episodes of relapse. Mucosal healing is an emerging therapeutic target in UC and various scoring systems have been used. The UC endoscopic index of severity (UCEIS) is the only validated endoscopic index at present, with minimum interobserver variation. Correlation of UCEIS scores after treatment and clinical outcomes of UC has not been examined. In the present study, we aimed to evaluate the usefulness of UCEIS after treatment with infliximab. Methods: The medical records of 82 UC patients, treated with infliximab at Keio University Hospital between October 2010 and July 2013, were reviewed retrospectively. Endoscopic findings were evaluated based on the UCEIS. Results: Mean pre-therapeutic UCEIS score was 5.1. Pre-therapeutic UCEIS scores were not associated with short-term outcomes. Forty-five patients underwent colonoscopy at 3–12 months after starting treatment; mean post-therapeutic UCEIS score was 2.4, with a score of 0–1 in 16 (35.6%) patients, 2–4 in 19 (42.2%) patients, and 5–8 in 10 (22.2%) patients. Importantly, a post-therapeutic UCEIS score of 0 or 1 after treatment was associated with a favorable long-term outcome. Conclusion: UCEIS score is a useful instrument for evaluating endoscopic improvement in UC patients treated with infliximab, and mucosal healing may be defined with a UCEIS score of 0 or 1.

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