Ultrastructure of the mouse synovial membrane. Development and organization of the extracellular matrix

Y. Okada, I. Nakanishi, K. Kajikawa

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

The synovial membrane of the mouse knee joint was examined by electron microscopy and electron microscopic histochemistry, with special reference to the development of the extracellular matrix. In the embryonic synovium, the intercellular spaces were filled with hyaluronate and chondroitin sulfate. The formation of the early joint cavity appeared to be initiated by accumulation of hyaluronate and chondroitin sulfate in the synovial primordium. At the postnatal stage, the synovial primordium differentiated into a true synovial intima that could be easily identified by the presence of two distinct lining cells: fibroblast-like cells (B cells) and phagocytic cells (A cells). Simultaneously, the synovial intima provided the specialized extracellular matrix that was characterized by organized structures of microfibrils, collagen fibers, and fibrous long spacing fibers embedded in a large number of glycoproteins.

Original languageEnglish
Pages (from-to)835-843
Number of pages9
JournalArthritis and Rheumatism
Volume24
Issue number6
Publication statusPublished - 1981

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Synovial Membrane
Chondroitin Sulfates
Extracellular Matrix
Microfibrils
Extracellular Space
Phagocytes
Knee Joint
Electron Microscopy
Glycoproteins
B-Lymphocytes
Collagen
Fibroblasts
Joints
Electrons

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Ultrastructure of the mouse synovial membrane. Development and organization of the extracellular matrix. / Okada, Y.; Nakanishi, I.; Kajikawa, K.

In: Arthritis and Rheumatism, Vol. 24, No. 6, 1981, p. 835-843.

Research output: Contribution to journalArticle

Okada, Y. ; Nakanishi, I. ; Kajikawa, K. / Ultrastructure of the mouse synovial membrane. Development and organization of the extracellular matrix. In: Arthritis and Rheumatism. 1981 ; Vol. 24, No. 6. pp. 835-843.
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