Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao, Takahiro Egawa, Kenjiro Hanaoka, Tetsuya Sakaguchi, Hiroyuki Hioki, Takeshi Kaneko, Shun Yamaguchi, Tetsuo Nagano, Norio Matsuki, Yuji Ikegaya

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)

Abstract

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

Original languageEnglish
Pages (from-to)503-505
Number of pages3
JournalNature Neuroscience
Volume17
Issue number4
DOIs
Publication statusPublished - 2014 Apr
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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