Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Mika Mizunuma; Hiroaki Norimoto; Kentaro Tao; Takahiro Egawa; Kenjiro Hanaoka; Tetsuya Sakaguchi; Hiroyuki Hioki; Takeshi Kaneko; Shun Yamaguchi; Tetsuo Nagano; Norio Matsuki; Yuji Ikegaya

doi:10.1038/nn.3674

Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Mika Mizunuma, Hiroaki Norimoto, Kentaro Tao, Takahiro Egawa, Kenjiro Hanaoka, Tetsuya Sakaguchi, Hiroyuki Hioki, Takeshi Kaneko, Shun Yamaguchi, Tetsuo Nagano, Norio Matsuki, Yuji Ikegaya

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

Original language	English
Pages (from-to)	503-505
Number of pages	3
Journal	Nature Neuroscience
Volume	17
Issue number	4
DOIs	https://doi.org/10.1038/nn.3674
Publication status	Published - 2014 Apr
Externally published	Yes

ASJC Scopus subject areas

Neuroscience(all)

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10.1038/nn.3674

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title = "Unbalanced excitability underlies offline reactivation of behaviorally activated neurons",

abstract = "Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.",

author = "Mika Mizunuma and Hiroaki Norimoto and Kentaro Tao and Takahiro Egawa and Kenjiro Hanaoka and Tetsuya Sakaguchi and Hiroyuki Hioki and Takeshi Kaneko and Shun Yamaguchi and Tetsuo Nagano and Norio Matsuki and Yuji Ikegaya",

note = "Funding Information: This work was supported by Grants-in-Aid for Science Research (22115003, 23115101, 25119004 and 25123709; the Japanese Ministry of Education, Culture, Sports, Science and Technology), the Funding Program for Next Generation World-Leading Researchers (LS023; the Japan Society for the Promotion of Science) and the Strategic Research Program for Brain Sciences.",

year = "2014",

month = apr,

doi = "10.1038/nn.3674",

language = "English",

volume = "17",

pages = "503--505",

journal = "Nature Neuroscience",

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T1 - Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

AU - Mizunuma, Mika

AU - Norimoto, Hiroaki

AU - Tao, Kentaro

AU - Egawa, Takahiro

AU - Hanaoka, Kenjiro

AU - Sakaguchi, Tetsuya

AU - Hioki, Hiroyuki

AU - Kaneko, Takeshi

AU - Yamaguchi, Shun

AU - Nagano, Tetsuo

AU - Matsuki, Norio

AU - Ikegaya, Yuji

N1 - Funding Information: This work was supported by Grants-in-Aid for Science Research (22115003, 23115101, 25119004 and 25123709; the Japanese Ministry of Education, Culture, Sports, Science and Technology), the Funding Program for Next Generation World-Leading Researchers (LS023; the Japan Society for the Promotion of Science) and the Strategic Research Program for Brain Sciences.

PY - 2014/4

Y1 - 2014/4

N2 - Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

AB - Hippocampal sharp waves (SWs)/ripples represent the reactivation of neurons involved in recently acquired memory and are crucial for memory consolidation. By labeling active cells with fluorescent protein under the control of an immediate-early gene promoter, we found that neurons that had been activated while mice explored a novel environment were preferentially reactivated during spontaneous SWs in hippocampal slices in vitro. During SWs, the reactivated neurons received strong excitatory synaptic inputs as opposed to a globally tuned network balance between excitation and inhibition.

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Unbalanced excitability underlies offline reactivation of behaviorally activated neurons

Abstract

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