Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins

Hironori Fujiwara, Koh Iwasaki, Katsutoshi Furukawa, Takashi Seki, Mei He, Masahiro Maruyama, Naoki Tomita, Yukitsuka Kudo, Makoto Higuchi, Takaomi C. Saido, Sumihiro Maeda, Akihiko Takashima, Masahiko Hara, Yasushi Ohizumi, Hiroyuki Arai

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77 Citations (Scopus)

Abstract

Because the deposition of β-amyloid protein (Aβ) is a consistent pathological hallmark of Alzheimer's disease (AD) brains, inhibition of Aβ generation, prevention of Aβ fibril formation, or destabilization of preformed Aβ fibrils would be attractive therapeutic strategies for the treatment of AD. We examined the effects of several medicinal herbs used in traditional Chinese medical formulae on the formation and destabilization of Aβ fibrils by using the thioflavin T binding assay, atomic force microscopic imaging, and electrophoresis. Our study demonstrates that several of these herbs have potent inhibitory effects on fibril formation of both Aβ1-40 and Aβ1-42 in concentration-dependent manners; in particular, Uncaria rhynchophylla inhibited Aβ aggregation most intensively. Significant destabilization of preformed Aβ1-40 and Aβ1-42 fibrils was also induced by Uncaria rhynchophylla as well as some other herb extracts. Three-dimensional HPLC analysis indicated that the water extract of this herb contains several different chemical compounds, including oxindole and indol alkaloids, which have been regarded as neuroprotective. Our results suggest that Uncaria rhynchophylla has remarkably inhibitory effects on the regulation of Aβ fibrils, and we conclude that this medicinal herb could have the potency to be a novel therapeutic agent to prevent and/or cure AD.

Original languageEnglish
Pages (from-to)427-433
Number of pages7
JournalJournal of neuroscience research
Volume84
Issue number2
DOIs
Publication statusPublished - 2006 Aug 1
Externally publishedYes

Keywords

  • Alzheimer's disease
  • Medicinal herb
  • Thioflavin T
  • Uncaria rhynchophylla
  • β-amyloid

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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  • Cite this

    Fujiwara, H., Iwasaki, K., Furukawa, K., Seki, T., He, M., Maruyama, M., Tomita, N., Kudo, Y., Higuchi, M., Saido, T. C., Maeda, S., Takashima, A., Hara, M., Ohizumi, Y., & Arai, H. (2006). Uncaria rhynchophylla, a Chinese medicinal herb, has potent antiaggregation effects on Alzheimer's β-amyloid proteins. Journal of neuroscience research, 84(2), 427-433. https://doi.org/10.1002/jnr.20891