Understanding the pathogenetic mechanisms of SIRS and sepsis and development of innovative therapies of sepsis

Naoki Aikawa, Seitaro Fujishima

Research output: Contribution to journalArticle


The concept of systemic inflammatory response syndrome (SIRS) was introduced in 1992 to define and objectively diagnose sepsis. Over the last decade, the definition of sepsis has been used for inclusion criteria of multicenter trials to develop innovative therapies of sepsis. With the recent understanding of the pathogenetic mechanisms of sepsis, many drugs have been tested, but only two drugs (activated protein C and neutrophil-elastase inhibitor) have been approved for clinical use in sepsis or SIRS. Further understanding of basic pathophysiology of SIRS and sepsis holds promise to develop a new therapeutic strategy to improve survival of patients with SIRS and sepsis.

Original languageEnglish
Pages (from-to)2173-2176
Number of pages4
JournalNippon rinsho. Japanese journal of clinical medicine
Issue number12
Publication statusPublished - 2004 Dec


ASJC Scopus subject areas

  • Medicine(all)

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