Unfolded protein response in osteoclastogenesis

Keisuke Horiuchi

Research output: Contribution to journalArticle

Abstract

Secreted proteins are synthesized and folded to acquire three-dimensional conformation in the endoplasmic reticulum(ER). Accumulation of unfolded proteins in the ER lumen triggers various cellular signals to remove these proteins and normalize the functions of the ER. This cellular mechanism is called the unfolded protein response(UPR)and medicated by three distinct signaling pathways in mammalian cells. Studies over the past decade have revealed that the UPR also has diverse functions that are not necessarily related to the maintenance of the ER. In osteoblasts and chondrocytes, it is now clear that the UPR not only functions to expand the capacity of the ER but also regulates the differentiation of these cells. Furthermore, recent studies suggest that the UPR is induced in osteoclast precursors after RANKL stimulation and has roles in osteoclastogenesis. This short review summarizes the findings of the recent studies on the unconventional roles of the UPR in osteoclast differentiation.

Original languageEnglish
Pages (from-to)601-608
Number of pages8
JournalClinical calcium
Volume26
Issue number4
Publication statusPublished - 2016 Apr 1

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Unfolded Protein Response
Osteogenesis
Endoplasmic Reticulum
Osteoclasts
Protein Unfolding
Chondrocytes
Osteoblasts
Cell Differentiation
Proteins
Maintenance

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Unfolded protein response in osteoclastogenesis. / Horiuchi, Keisuke.

In: Clinical calcium, Vol. 26, No. 4, 01.04.2016, p. 601-608.

Research output: Contribution to journalArticle

Horiuchi, K 2016, 'Unfolded protein response in osteoclastogenesis', Clinical calcium, vol. 26, no. 4, pp. 601-608.
Horiuchi, Keisuke. / Unfolded protein response in osteoclastogenesis. In: Clinical calcium. 2016 ; Vol. 26, No. 4. pp. 601-608.
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