Unusual intramolecular N→O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine

Ikuko Kozawa, Kuniki Kato, Toshiaki Teruya, Kiyotake Suenaga, Kazuo Umezawa

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Previously we found that (-)-DHMEQ, a specific NF-κB inhibitor, covalently bound to a specific cysteine of NF-κB component proteins. In the course of formation of the (-)-DHMEQ and protected cysteine conjugate, we observed an unusual intramolecular N→O acyl group migration.

Original languageEnglish
Pages (from-to)5380-5382
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume19
Issue number18
DOIs
Publication statusPublished - 2009 Sep 15

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Cysteine
Proteins
IgA receptor

Keywords

  • (-)-DHMEQ
  • Bioconjugate
  • Cysteine
  • NF-κB
  • Rearrangement

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry
  • Molecular Medicine
  • Molecular Biology
  • Clinical Biochemistry
  • Biochemistry

Cite this

Unusual intramolecular N→O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine. / Kozawa, Ikuko; Kato, Kuniki; Teruya, Toshiaki; Suenaga, Kiyotake; Umezawa, Kazuo.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 19, No. 18, 15.09.2009, p. 5380-5382.

Research output: Contribution to journalArticle

Kozawa, Ikuko ; Kato, Kuniki ; Teruya, Toshiaki ; Suenaga, Kiyotake ; Umezawa, Kazuo. / Unusual intramolecular N→O acyl group migration occurring during conjugation of (-)-DHMEQ with cysteine. In: Bioorganic and Medicinal Chemistry Letters. 2009 ; Vol. 19, No. 18. pp. 5380-5382.
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