Unveiling cellular biochemical reactions via metabolomics-driven approaches

Natsumi Saito, Yoshiaki Ohashi, Tomoyoshi Soga, Masaru Tomita

Research output: Contribution to journalReview article

23 Citations (Scopus)

Abstract

Despite the widespread availability of genome sequences and the systematic assignment of individual open reading frames, many of the activities of metabolic enzymes are still veiled. It is difficult to assign biochemical functions to enzymes and uncover the in vivo regulation of their enzymatic activities, but this is crucial to understand cellular functions. The development of metabolomics and metabolite profiling, which can globally analyze intracellular and extracellular metabolites, has provided some valuable tools for systems biology. This report reviews the recent metabolomics approaches to elucidate unidentified metabolic systems while focusing on their enzymatic activities, including their biochemical and biological functions, and their regulation in response to environmental perturbations in microorganisms.

Original languageEnglish
Pages (from-to)358-362
Number of pages5
JournalCurrent Opinion in Microbiology
Volume13
Issue number3
DOIs
Publication statusPublished - 2010 Jun 1

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ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)
  • Infectious Diseases

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