Up-regulated expression of murine Mcl1/EAT, a Bcl-2 related gene, in the early stage of differentiation of murine embryonal carcinoma cells and embryonic stem cells

Hajime Okita, Akihiro Umezawa, Atsushi Suzuki, Jun Ichi Hata

Research output: Contribution to journalArticlepeer-review

24 Citations (Scopus)

Abstract

We have cloned a murine homologue of the human Mcl1/EAT gene, a Bcl-2 related gene. Sequence analysis revealed that murine Mcl1/EAT (mMcl1/EAT) has three Bcl-2 homology domains, two PEST sequences, and immediate response boxes (IRB). The presence of IRB indicates that mMcl1/EAT is an immediate- early gene. mMcl1/EAT increases dramatically with exposure to retinoic acid in murine embryonal carcinoma cell lines (F9 and PCC3) as well as embryonic stem cells, both of which are models of early embryogenesis.

Original languageEnglish
Pages (from-to)335-341
Number of pages7
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1398
Issue number3
DOIs
Publication statusPublished - 1998 Jul 9

Keywords

  • (Mouse)
  • Bcl-2
  • Embryonal carcinoma
  • Embryonic stem cell
  • Mcll/EAT
  • cDNA

ASJC Scopus subject areas

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

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