Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chicks (Gallus gallus domesticus)

Shinji Yamaguchi, Ikuko Fujii-Taira, Akio Murakami, Naoki Hirose, Naoya Aoki, Ei Ichi Izawa, Yasuyuki Fujimoto, Tatsuya Takano, Toshiya Matsushima, Koichi J. Homma

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23 Citations (Scopus)

Abstract

Using cDNA microarrays, we have identified elsewhere the genes of microtubule-associated proteins as a group up-regulated in newly hatched chick brains after filial imprinting training. Here we show by in situ hybridization that the mRNA for the microtubule-associated protein 2 (MAP2) gene was enriched in the mesopallium and the hippocampus in the trained chick brain. The regionally specific enrichments of MAP2 mRNA were not observed in the brain of dark-reared or light-exposed chick as controls, implying an association between the degree of expression and the strength of the learned preference. In agreement with the gene expression, MAP2 protein was accumulated in the mesopallium of the trained chick brain, but not in the brains of the controls. The accumulation of MAP2 was found in the cytosol of neurons and co-localized with β-tubulin, suggesting a change in microtubule assembly. Our results suggest a postnatal reorganization of cytoskeleton following filial imprinting.

Original languageEnglish
Pages (from-to)282-288
Number of pages7
JournalBrain Research Bulletin
Volume76
Issue number3
DOIs
Publication statusPublished - 2008 Jun 15

Keywords

  • Behavior
  • Chick
  • Filial imprinting
  • Gallus gallus domesticus
  • MAP2
  • Microtubule

ASJC Scopus subject areas

  • Neuroscience(all)

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    Yamaguchi, S., Fujii-Taira, I., Murakami, A., Hirose, N., Aoki, N., Izawa, E. I., Fujimoto, Y., Takano, T., Matsushima, T., & Homma, K. J. (2008). Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chicks (Gallus gallus domesticus). Brain Research Bulletin, 76(3), 282-288. https://doi.org/10.1016/j.brainresbull.2008.02.010