Update on the indications and results of sentinel node mapping in upper GI cancer

Masashi Takeuchi, Hiroya Takeuchi, Hirofumi Kawakubo, Yuukou Kitagawa

Research output: Contribution to journalArticle

Abstract

The clinical utilization of sentinel node (SN) mapping for early esophageal cancer or gastric cancer has been unclear for a long time. However, previous investigations regarding SN mapping of these cancers have shown relatively good results with regard to the detection rate and diagnostic accuracy for determining the lymph node status. SN mapping helps obtain information about individual metastatic status and allows the modification of the operation in early-stage upper gastrointestinal (GI) disease. Radio-guided methods for identifying SNs in early esophageal cancer have been established via endoscopic injection of technetium-99m tin colloid. Previous studies have reported that the SN concept seems valid, and radio-guided SN mapping can be feasible in cT1N0 esophageal cancer. SN navigation surgery are believed to have potential as strategies for minimally invasive modified surgery for early esophageal cancer. A Japanese study group conducted a prospective multicenter trial of SN mapping for early gastric cancer using a dual tracer method with radioactive colloid and blue dyes; they demonstrated a high detection rate and accuracy for determining the metastatic status based on SN mapping. Subsequently, minimized gastrectomy, including partial gastrectomy and segmental gastrectomy with individualized selective and modified lymphadenectomy for early gastric cancer with a negative SN has been performed to evaluate the long-term survival and postoperative quality of life (QOL) in a multicenter prospective trial. This study verified the SN concept in early-stage upper GI disease with cN0 and found that function-preserving esophagectomy or gastrectomy may help maintain patients’ post-surgical QOL.

Original languageEnglish
JournalClinical and Experimental Metastasis
DOIs
Publication statusAccepted/In press - 2018 Jan 1

Fingerprint

Gastrointestinal Neoplasms
Gastrectomy
Esophageal Neoplasms
Stomach Neoplasms
Gastrointestinal Diseases
Radio
Multicenter Studies
Quality of Life
cyhalothrin
Esophagectomy
Minimally Invasive Surgical Procedures
Technetium
Colloids
Lymph Node Excision
Coloring Agents
Lymph Nodes
Injections

Keywords

  • Esophageal cancer
  • Gastric cancer
  • Sentinel node

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Update on the indications and results of sentinel node mapping in upper GI cancer. / Takeuchi, Masashi; Takeuchi, Hiroya; Kawakubo, Hirofumi; Kitagawa, Yuukou.

In: Clinical and Experimental Metastasis, 01.01.2018.

Research output: Contribution to journalArticle

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