Uptake of cadmium in meals from the digestive tract of young non-smoking Japanese female volunteers

Yuriko Kikuchi, Tetsuo Nomiyama, Nami Kumagai, Fumiko Dekio, Takamoto Uemura, Toru Takebayashi, Yuji Nishiwaki, Yukio Matsumoto, Yuri Sano, Kanae Hosoda, Shaw Watanabe, Haruhiko Sakurai, Kazuyuki Omae

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Abstract

Objectives - To estimate rates of cadmium (Cd) uptake from the digestive tract and changes in Cd in biological specimens after intake of Cd mainly in rice. Methods - Twenty-five young non-smoking Japanese female volunteers (20-23 in age) were recruited and a 20-d experimental study was conducted. With polished rice containing 0.004 ppm and 0.340 ppm of Cd, Meal L and Meal H were prepared. Approximately 12% of total Cd in Meal L and 92% of total Cd in Meal H originated in rice. The volunteers ate Meal L for 11 d to achieve a stable intake-output balance of Cd. Fifteen of the 25 volunteers ate Meal H on the 12th day (Group D1), and the remaining 10 ate Meal H on the 12th, 13th and 14th day (Group D3). All 25 subjects then resumed the consumption of Meal L to the end of the study (20th day). All meals, feces and urine were collected during the study, and Cd intake from the daily meals (Cd-I), Cd in feces (Cd-F) and Cd in urine (Cd-U) were determined. For measurement of Cd in blood (Cd-B), venous blood was collected from all volunteers on the day before the study and again on the 12th and 20th day; venous blood was also collected from 4-8 volunteers at additional time points. Results - Mean Cd-I was 4.51 μg/d (range: 1.85-6.93) or 48.48 μg/d (range: 27.98-56.27) when they ate Meal L or Meal H. Cd-F and Cd-B exhibited faster responses to the change in Cd-I than did Cd-U. The Cduptake rate, defined as (1-Cd-Fexcess/Cd-Iexcess) (Fig. 1), was 47.2% (range: -9.4-83.3%) in Group D1 and 36.6% (range: -9.2-73.5%) in Group D3, and the Cdbalance rate, defined as (1-Cd-Foutput/Cd-Iintake), was 23.9% (range: -4.0-37.7%) in Group D1 and 23.7% (range: -8.2-56.9%) in Group D3. Conclusions - Cd-F and Cd-B are better biological monitoring parameters for assessing change in Cd-I than Cd-U. The Cduptake and Cdbalance rates appeared to be higher than those in previous papers when ingested Cd mainly originated in rice.

Original languageEnglish
Pages (from-to)43-52
Number of pages10
JournalJournal of occupational health
Volume45
Issue number1
DOIs
Publication statusPublished - 2003 Jan

Keywords

  • Absorption
  • Biological monitoring
  • Cadmium
  • Dietary intake
  • Rice
  • Volunteer experiment

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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    Kikuchi, Y., Nomiyama, T., Kumagai, N., Dekio, F., Uemura, T., Takebayashi, T., Nishiwaki, Y., Matsumoto, Y., Sano, Y., Hosoda, K., Watanabe, S., Sakurai, H., & Omae, K. (2003). Uptake of cadmium in meals from the digestive tract of young non-smoking Japanese female volunteers. Journal of occupational health, 45(1), 43-52. https://doi.org/10.1539/joh.45.43