Urinary dysfunction in early and untreated Parkinson's disease

Tomoyuki Uchiyama, Ryuji Sakakibara, Tatsuya Yamamoto, Takashi Ito, Chiharu Yamaguchi, Yusuke Awa, Mitsuru Yanagisawa, Yoshinori Higuchi, Yasunori Sato, Tomohiko Ichikawa, Tomonori Yamanishi, Takamichi Hattori, Satoshi Kuwabara

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Background: Urinary dysfunction is common in Parkinson's disease (PD); however, little is known about urinary dysfunction in early and untreated PD patients. Methods: Fifty consecutive untreated PD patients (mean age, 66.7; mean disease duration, 23.6 months; and mean Hoehn & Yahr scale, 1.9) were recruited; those with other conditions that might have influenced urinary function were excluded. Patients were evaluated using a urinary questionnaire and urodynamic studies. Results: Sixty-four per cent complained of urinary symptoms (storage, 64.0%; voiding, 28.0%). Urodynamic studies showed abnormal findings in the storage phase in 84%, with detrusor overactivity (DO) and increased bladder sensation without DO in 58.0% and 12.0% of patients, respectively. In the voiding phase, detrusor underactivity, impaired urethral relaxation such as detrusor sphincter dyssynergia, and bladder outlet obstruction were present in 50.0%, 8.0% and 16% of patients, respectively. In patients with both storage and voiding phase abnormalities, DO+detrusor underactivity was the most common finding. Few patients experienced urge incontinence and/or quality-of-life impairment owing to urinary dysfunction; none had low-compliance bladder or abnormal anal-sphincter motor unit potential. These urinary symptoms and urodynamic findings were not correlated with gender, disease severity or motor symptom type. Conclusion: Urinary dysfunction, manifested primarily as storage disorders with subclinical voiding disorders and normal anal-sphincter electromyography, occurs in early and untreated PD patients. In cases with severe voiding disorder and/or abnormal anal-sphincter electromyography, other diagnoses should be considered.

Original languageEnglish
Pages (from-to)1382-1386
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume82
Issue number12
DOIs
Publication statusPublished - 2011 Jan 1
Externally publishedYes

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Parkinson Disease
Urodynamics
Anal Canal
Electromyography
Urinary Bladder
Urinary Bladder Neck Obstruction
Urge Urinary Incontinence
Ataxia
Compliance
Quality of Life

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Uchiyama, T., Sakakibara, R., Yamamoto, T., Ito, T., Yamaguchi, C., Awa, Y., ... Kuwabara, S. (2011). Urinary dysfunction in early and untreated Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry, 82(12), 1382-1386. https://doi.org/10.1136/jnnp.2011.241075

Urinary dysfunction in early and untreated Parkinson's disease. / Uchiyama, Tomoyuki; Sakakibara, Ryuji; Yamamoto, Tatsuya; Ito, Takashi; Yamaguchi, Chiharu; Awa, Yusuke; Yanagisawa, Mitsuru; Higuchi, Yoshinori; Sato, Yasunori; Ichikawa, Tomohiko; Yamanishi, Tomonori; Hattori, Takamichi; Kuwabara, Satoshi.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 82, No. 12, 01.01.2011, p. 1382-1386.

Research output: Contribution to journalArticle

Uchiyama, T, Sakakibara, R, Yamamoto, T, Ito, T, Yamaguchi, C, Awa, Y, Yanagisawa, M, Higuchi, Y, Sato, Y, Ichikawa, T, Yamanishi, T, Hattori, T & Kuwabara, S 2011, 'Urinary dysfunction in early and untreated Parkinson's disease', Journal of Neurology, Neurosurgery and Psychiatry, vol. 82, no. 12, pp. 1382-1386. https://doi.org/10.1136/jnnp.2011.241075
Uchiyama T, Sakakibara R, Yamamoto T, Ito T, Yamaguchi C, Awa Y et al. Urinary dysfunction in early and untreated Parkinson's disease. Journal of Neurology, Neurosurgery and Psychiatry. 2011 Jan 1;82(12):1382-1386. https://doi.org/10.1136/jnnp.2011.241075
Uchiyama, Tomoyuki ; Sakakibara, Ryuji ; Yamamoto, Tatsuya ; Ito, Takashi ; Yamaguchi, Chiharu ; Awa, Yusuke ; Yanagisawa, Mitsuru ; Higuchi, Yoshinori ; Sato, Yasunori ; Ichikawa, Tomohiko ; Yamanishi, Tomonori ; Hattori, Takamichi ; Kuwabara, Satoshi. / Urinary dysfunction in early and untreated Parkinson's disease. In: Journal of Neurology, Neurosurgery and Psychiatry. 2011 ; Vol. 82, No. 12. pp. 1382-1386.
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