Urinary podocalyxin levels were associated with urinary albumin levels among patients with diabetes

M. Shoji, K. Kobayashi, M. Takemoto, Y. Sato, K. Yokote

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Diabetic nephropathy has dramatically increased worldwide. In this study, we measured urinary podocalyxin in 240 patients with diabetes. The relationship between urinary podocalyxin and clinical parameters and the effects of dipeptidyl peptidase-4 inhibitors (DPP4i) and alpha-glucosidase inhibitor (a-GI) on urinary podocalyxin levels were examined. Urinary podocalyxin levels were significantly higher in patients with microalbuminuria than in those with normoalbuminuria. Urinary podocalyxin levels were also significantly related to albumin-to-creatinine ratio. Neither DPP4i nor α-GI ameliorated the increase in urinary podocalyxin levels. Our results indicated that urinary podocalyxin will be not only an early marker but also a treatment target for DN.

Original languageEnglish
Pages (from-to)164-167
Number of pages4
JournalBiomarkers
Volume21
Issue number2
DOIs
Publication statusPublished - 2016 Feb 17

Keywords

  • Biomarker
  • diabetic nephropathy
  • podocyte
  • urinary podocalyxin

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry
  • Health, Toxicology and Mutagenesis

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