Urinary steroid profile in adrenocortical tumors

Eiji Kikuchi, H. Yanaihara, J. Nakashima, K. Homma, T. Ohigashi, H. Asakura, M. Tachibana, H. Shibata, T. Saruta, M. Murai

Research output: Contribution to journalArticle

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Abstract

Determination of the urinary steroid profile has been proposed as a sensitive tool for diagnosing adrenocortical tumors. The urinary steroid profiles were determined for patients with adrenocortical tumors. Urinary steroids were extracted, derivatized to form methyloxime-trimethylsilyl ether and analyzed by gas chromatography/mass spectrometry. Patients with adrenal adenomas from primary hyperaldosteronism had increased metabolites of 18- hydroxycorticosterone and aldosterone, and those with Cushing's syndrome had elevated excretion of 11-deoxycortisol, cortisol, 18-hydroxycortisol, and cortisone metabolites. In patients with adrenocortical carcinomas, increased levels of metabolites of 11-deoxycortisol or 3β-hydroxy-5-ene steroids were observed. The urinary steroid profiles of adrenal adenomas and adrenocortical carcinomas were quite different, suggesting the diagnostic validity for discriminating malignant from benign diseases. (C) 2000 Editions scientifiques et medicales Elsevier SAS.

Original languageEnglish
JournalBiomedicine and Pharmacotherapy
Volume54
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2000 Jun

Fingerprint

Steroids
Cortodoxone
Adrenocortical Carcinoma
Neoplasms
Adenoma
18-Hydroxycorticosterone
Hyperaldosteronism
Cushing Syndrome
Cortisone
Aldosterone
Ether
Gas Chromatography-Mass Spectrometry
Hydrocortisone

Keywords

  • Adrenocortical tumor
  • Steroidogenesis
  • Urine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Kikuchi, E., Yanaihara, H., Nakashima, J., Homma, K., Ohigashi, T., Asakura, H., ... Murai, M. (2000). Urinary steroid profile in adrenocortical tumors. Biomedicine and Pharmacotherapy, 54(SUPPL. 1). https://doi.org/10.1016/S0753-3322(00)80043-8

Urinary steroid profile in adrenocortical tumors. / Kikuchi, Eiji; Yanaihara, H.; Nakashima, J.; Homma, K.; Ohigashi, T.; Asakura, H.; Tachibana, M.; Shibata, H.; Saruta, T.; Murai, M.

In: Biomedicine and Pharmacotherapy, Vol. 54, No. SUPPL. 1, 06.2000.

Research output: Contribution to journalArticle

Kikuchi, E, Yanaihara, H, Nakashima, J, Homma, K, Ohigashi, T, Asakura, H, Tachibana, M, Shibata, H, Saruta, T & Murai, M 2000, 'Urinary steroid profile in adrenocortical tumors', Biomedicine and Pharmacotherapy, vol. 54, no. SUPPL. 1. https://doi.org/10.1016/S0753-3322(00)80043-8
Kikuchi E, Yanaihara H, Nakashima J, Homma K, Ohigashi T, Asakura H et al. Urinary steroid profile in adrenocortical tumors. Biomedicine and Pharmacotherapy. 2000 Jun;54(SUPPL. 1). https://doi.org/10.1016/S0753-3322(00)80043-8
Kikuchi, Eiji ; Yanaihara, H. ; Nakashima, J. ; Homma, K. ; Ohigashi, T. ; Asakura, H. ; Tachibana, M. ; Shibata, H. ; Saruta, T. ; Murai, M. / Urinary steroid profile in adrenocortical tumors. In: Biomedicine and Pharmacotherapy. 2000 ; Vol. 54, No. SUPPL. 1.
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